ArticleAnnals of medicine and surgery (2012)2024
Antinociceptive effects of gamma-linolenic acid in the formalin test in the rats.
Article in Annals of medicine and surgery (2012), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Multi-dimensional analysis of quality differences among four cultivars of bamboo shoots.Food chemistry: X · 2026Article
- Isolation of 3β-Hydroxylupenal From Ceriops decandra Leaves and Evaluation of In Vivo Analgesic and Anti-Inflammatory Effects Supported by Molecular Docking.BioMed research international · 2026Article
- Article
- Jasmine sambac L. essential oil attenuates inflammation and pain via TRPV1.Inflammopharmacology · 2025Article
- Effects of dimethyl itaconate on expressions of NGFI-A and NGFI-B and inflammatory cytokines in the spinal cord in the formalin test.Brain communications · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gamma-linolenic acid (GLA) is found in animals and plants that play a role in brain function and metabolism. Objective: This study aimed to investigate the analgesic effects of GLA on peripheral formalin injection. Methods: Wistar rats were randomly assigned to four groups: Sham, formalin, formalin/GLA 100 mg/kg, and formalin/GLA 150 mg/kg. The Formalin test was utilized to create a pain model. A tissue sample was prepared from the spinal cords of rats to measure oxidative stress parameters and pro-inflammatory cytokines. Furthermore, the authors analyzed the expression of c-Fos protein in the spinal cords. Results: Our findings demonstrate that GLA has a reliable pain-relieving effect in the formalin test. GLA 100 increased superoxide dismutase (SOD) ( Conclusion: The findings have validated the antinociceptive impact of GLA and hinted towards its immunomodulatory influence in the formalin test.
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Registered trials
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