ReviewAnnals of medicine and surgery (2012)2024
Role of cytokines in immunomodulation during malaria clearance.
Review in Annals of medicine and surgery (2012), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Neutrophil Fate and Function in Gout: From Sterile Inflammation to Resolution.International journal of molecular sciences · 2026Review
- Immunomodulation Therapy to Treat Severe Malaria With Multiple Organ Failure.Critical care explorations · 2026Article
- Article
- Parity differences and inflammatory signatures relative to neonatal nutritional status in a community near the Atlantic Ocean coastline of Lagos, Southwest Nigeria: a cross-sectional study.BMC pediatrics · 2026Article
- Helminth-infected Mozambican children with malaria have increased anaemia, cytokines and helminth-specific antibodies.PLoS neglected tropical diseases · 2026Article
- Cellular nucleic acid-binding protein (CNBP) dependent cytokine programming shapes host defense againstbioRxiv : the preprint server for biology · 2026Article
- Current State of the Fight Against Antimicrobial Resistance: What Are the Different Strategies for Tomorrow?Antibiotics (Basel, Switzerland) · 2026Review
- Hidden hematological, biochemical and immune costs of asymptomatic malaria infections in semi-wild chimpanzees.PLoS pathogens · 2026Article
- Mature-StageInternational journal of molecular sciences · 2026Article
- A Trypanothione Synthetase-Based Subunit Vaccine Induces Protective Th1 Immunity against Visceral Leishmaniasis in Mice.ACS pharmacology & translational science · 2026Article
- Incidence and risk factors of malaria with hematological and immunological evaluation and integrable analysis of a fractional mathematical model.Scientific reports · 2026Article
- Distinct systemic cytokine signatures define symptomatic malaria in children: insights from a longitudinal study in Togo.BMC infectious diseases · 2026Article
- The eye as a gateway to the brain: mechanisms of ocular neuroinvasion by parasitic pathogens.GMS hygiene and infection control · 2026Article
- Hidden hematological, biochemical and immune costs of asymptomatic malaria infections in semi-wild chimpanzees.bioRxiv : the preprint server for biology · 2025Article
- Overview of the host immune response toJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Correlation of Inflammatory Biomarkers and IgG4 Antibodies with Malaria in Cameroon's Buea Municipality Children.Diseases (Basel, Switzerland) · 2025Article
- Exploring Biomarkers for Malaria: Advances in Early Detection and Asymptomatic Diagnosis.Biosensors · 2025Review
- Malaria and dyserythropoiesis: a mini review.Frontiers in cellular and infection microbiology · 2025Review
- Emerging public health strategies in malaria control: innovations and implications.Annals of medicine and surgery (2012) · 2024Review
- Prevalence Study ofAnimals : an open access journal from MDPI · 2024Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria remains a significant global health challenge, demanding a deeper understanding of host immune responses for effective clearance of the parasitic infection. Cytokines, as crucial mediators of the immune system, orchestrate a complex interplay during the various stages of malaria infection. Throughout the course of the disease, an intricate balance of pro-inflammatory and anti-inflammatory cytokines dictate the immune response's outcome, influencing parasitic clearance and disease severity. During the initial stages, interleukins such as interleukin-12 (IL-12), interferon-gamma (IFN-γ), and tumour necrosis factor-alpha (TNF-α) play pivotal roles in activating innate immune cells, initiating the anti-parasitic response. Simultaneously, regulatory cytokines like interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β) modulate this immune activation, preventing excessive inflammation and tissue damage. As the infection progresses, a delicate shift occurs, characterized by a transition to adaptive immunity, guided by cytokines like interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13), promoting antibody production and T-cell responses. Notably, the resolution of malaria infection crucially relies on a fine-tuned balance of cytokine networks. Dysregulation or imbalances in these mediators often result in immune hyperactivation, contributing to severe manifestations and prolonged infection. Understanding the multi-faceted roles of cytokines in malaria clearance offers promising avenues for therapeutic interventions. Targeting cytokine pathways to restore immune equilibrium or bolster protective responses could potentially enhance treatment strategies and vaccine development. In conclusion, the pivotal role of cytokines in immunomodulation during malaria clearance underscores their significance as potential targets for therapeutic interventions, offering promising prospects in the global fight against this infectious disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.