Evidence map›Paper›PMID 38694206›Full record

ArticleFrontiers in physiology2024

The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance.

Rakhee Banerjee, Rachel C Hohe, Shijie Cao, Bryan M Jung, Anthony J Horak, Iyappan Ramachandiran, William J Massey, Venkateshwari Varadharajan, Natalie I Zajczenko, Amy C Burrows and 14 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Nonvesicular cholesterol transport in physiology.The Journal of clinical investigation · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 2 countries.

Rakhee BanerjeeDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Rachel C HoheDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Shijie CaoDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Bryan M JungDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Anthony J HorakCenter for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Iyappan RamachandiranCenter for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
William J MasseyDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Venkateshwari VaradharajanDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Natalie I ZajczenkoDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Amy C BurrowsDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Sumita DuttaDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Maryam GoudarziDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Kala MahenDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Abigail CarterDepartment of Physiology and the Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, KY, United States.
Robert N HelsleyDepartment of Physiology and the Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, KY, United States.
Scott M GordonDepartment of Physiology and the Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, KY, United States.
Richard E MortonDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland, OH, United States.
Christopher StrauchProteomics and Metabolomics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Belinda WillardProteomics and Metabolomics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Camelia Baleanu GogoneaDepartment of Chemistry, Cleveland State University, Cleveland, OH, United States.
Valentin GogoneaDepartment of Chemistry, Cleveland State University, Cleveland, OH, United States.
Matteo PedrelliDepartment of Laboratory Medicine, Karolinska Institute, Huddinge, Sweden.
Paolo PariniDepartment of Laboratory Medicine, Karolinska Institute, Huddinge, Sweden.
J Mark BrownDepartment of Cancer Biology, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, United States.
Cleveland Clinic Lerner College of Medicine · USDivision of Chemistry · USKarolinska Institutet · SEUniversity of Kentucky · USCardiovascular Research Associates · US

Funding

Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2016 to 2026
$19.6M
Project 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Stanley L Hazen · 2019 to 2026
$17.0M
West Coast Metabolomics Center for Compound IdentificationU2CES030158 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2018 to 2021
$4.1M
Metaorganismal Endocrinology in Cardiometabolic DiseaseR01DK130227 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Jonathan Mark Brown · 2021 to 2026
$2.8M
Dark GPCR signaling underlying the Microbiome-Gut-Brain Axis for Alzheimer's Disease and Related DementiaRF1NS133812 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BROWN, JONATHAN MARK, CHENG, FEIXIONG · 2023 to 2023
$2.3M
The Role of Bacterial Choline Metabolism in Host Stress ResponsesR01DK120679 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI BROWN, JONATHAN MARK · 2019 to 2022
$1.6M
NHLBI NIH HHS P01 HL147823NIAAA NIH HHS P50 AA024333NIDDK NIH HHS R01 DK120679NIDDK NIH HHS R01 DK130227NIEHS NIH HHS U2C ES030158NINDS NIH HHS RF1 NS133812
6 · The paper itself

Abstract

Introduction: The Aster-C protein (encoded by the Method: Age-matched Results: Compared to wild type controls ( Discussion: Collectively, these data indicate nominal effects of Aster-C on whole body cholesterol transport and metabolism under divergent dietary cholesterol conditions. These results strongly suggest that Aster-C alone is not sufficient to control whole body cholesterol balance, but can modestly impact circulating cortisol and bile acid levels when dietary cholesterol is limited.

Indexed as

cholesterollipoproteinmetabolismoxysterolsteroid hormone

Identifiers

PMID38694206
PMCPMC11061533
OpenAlexW4394887837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.