Evidence map›Paper›PMID 38694051›Full record

ReviewHeliyon2024

Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery.

Shamama Javed, Bharti Mangla, Muhammad H Sultan, Yosif Almoshari, Durgaramani Sivadasan, Saad S Alqahtani, Osama A Madkhali, Waquar Ahsan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.Green chemistry : an international journal and green chemistry resource : GC · 2025
    Review
  16. Terpene-Based Eutectic Solvent Microdroplets: A Strategy to Combat Antibiotic-ResistantLangmuir : the ACS journal of surfaces and colloids · 2025
    Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shamama JavedDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.
Bharti ManglaDepartment of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi, 110017, India.
Muhammad H SultanDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.
Yosif AlmoshariDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.
Durgaramani SivadasanDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.
Saad S AlqahtaniDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Osama A MadkhaliDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.
Waquar AhsanDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The issue of poor solubility of active pharmaceutical ingredients (APIs) has been a salient area of investigation and novel drug delivery systems are being developed to improve the solubility of drugs, enhance their permeability and thereby their efficacy. Several techniques for solubilization enhancement of poorly soluble drugs are often employed at various stages of pharmaceutical drug product development. One such delivery system is the therapeutic deep eutectic system (THEDES), which showed great potential in the enhancement of solubility and permeability of drugs and ultimately augmenting their bioavailability. THEDES are made by mixing drugs with deep eutectic solvents (DESs) in a definite molar ratio by the hit and trial method. The DESs are a new class of green solvents which are non-toxic, cheap, easy to prepare, biodegradable and have multiple applications in the pharmaceutical industry. The terminologies such as ionic liquids (ILs), DES, THEDES, and therapeutic liquid eutectic systems (THELES) have been very much in use recently, and it is important to highlight the pharmaceutical applications of these unexplored reservoirs in drug solubilization enhancement, drug delivery routes, and in the management of various diseases. This review is aimed at discussing the components, formulation strategies, and routes of administration of THEDES that are used in developing the formulation. Also, the major pharmaceutical applications of THEDES in the treatment of various metabolic and non-metabolic diseases are reviewed.

Indexed as

BioavailabilityDeep eutectic solventsIonic liquidsPermeabilitySolubilityTherapeutic deep eutectic system

Identifiers

PMID38694051
PMCPMC11058303

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.