Evidence map›Paper›PMID 38693998›Full record

ArticleAdvanced functional materials2024

A Protein-Adsorbent Hydrogel with Tunable Stiffness for Tissue Culture Demonstrates Matrix-Dependent Stiffness Responses.

Linqing Li, Megan E Griebel, Marina Uroz, Saniya Yesmin Bubli, Keith A Gagnon, Britta Trappmann, Brendon M Baker, Jeroen Eyckmans, Christopher S Chen

Open access · greenAbstract read
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Living Hydrogels: Harnessing Microorganism-Material Synergy for Next-Generation Therapeutics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Linqing LiDepartment of Biomedical Engineering, Biological Design Center, Boston University, Boston, MA, 02215, United States.
Megan E GriebelDepartment of Biomedical Engineering, Biological Design Center, Boston University, Boston, MA, 02215, United States.
Marina UrozDepartment of Biomedical Engineering, Biological Design Center, Boston University, Boston, MA, 02215, United States.
Saniya Yesmin BubliDepartment of Chemical Engineering and Bioengineering, University of New Hampshire, Durham, New Hampshire, 03824, United States.
Keith A GagnonDepartment of Biomedical Engineering, Biological Design Center, Boston University, Boston, MA, 02215, United States.
Britta TrappmannBioactive Materials Laboratory, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, Münster, 48149 Germany.
Brendon M BakerEngineered Microenvironments and Mechanobiology Lab, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109 United States.
Jeroen EyckmansDepartment of Biomedical Engineering, Biological Design Center, Boston University, Boston, MA, 02215, United States.
Christopher S ChenDepartment of Biomedical Engineering, Biological Design Center, Boston University, Boston, MA, 02215, United States.
Boston University · USMax Planck Institute for Molecular Biomedicine · DEUniversity of Michigan · USUniversity of New Hampshire · US

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI DON Michael WOJCHOWSKI · 2017 to 2026
$22.8M
REGULATION OF ANGIOGENESIS BY MICROENVIRONMENTAL CUESR01EB000262 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHRISTOPHER S · 2002 to 2023
$6.2M
Engineering Multicellular Tissue Structure, Function, and VascularizationR01EB008396 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI BHATIA, SANGEETA N., CHEN, CHRISTOPHER S · 2009 to 2018
$5.8M
Development of a wound-on-chip model to study stromal-epithelial interactions during tissue repairR21EB028491 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI EYCKMANS, JEROEN · 2020 to 2022
$660k
NIBIB NIH HHS R01 EB000262NIBIB NIH HHS R01 EB008396NIBIB NIH HHS R21 EB028491NIGMS NIH HHS P20 GM113131
6 · The paper itself

Abstract

Although tissue culture plastic has been widely employed for cell culture, the rigidity of plastic is not physiologic. Softer hydrogels used to culture cells have not been widely adopted in part because coupling chemistries are required to covalently capture extracellular matrix (ECM) proteins and support cell adhesion. To create an

Indexed as

cell adhesiondextranextra-cellular matrixhydrogelnon-swellingprotein adsorbenttissue culture

Identifiers

PMID38693998
PMCPMC11060701
OpenAlexW4390745031

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.