Evidence map›Paper›PMID 38693565›Full record

ArticleRetrovirology2024

Inhibition of caspase pathways limits CD4

Alex J Holloway, Tais B Saito, Kubra F Naqvi, Matthew B Huante, Xiuzhen Fan, Joshua G Lisinicchia, Benjamin B Gelman, Janice J Endsley, Mark A Endsley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Retrovirology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alex J HollowayDepartment of Microbiology and Immunology, University of Texas Medical Branch, 77555, Galveston, TX, USA.
Tais B SaitoDepartment of Pathology, University of Texas Medical Branch, 77555, Galveston, TX, USA.
Kubra F NaqviDepartment of Microbiology and Immunology, University of Texas Medical Branch, 77555, Galveston, TX, USA.
Matthew B HuanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, 77555, Galveston, TX, USA.
Xiuzhen FanDepartment of Microbiology and Immunology, University of Texas Medical Branch, 77555, Galveston, TX, USA.
Joshua G LisinicchiaDepartment of Pathology, University of Texas Medical Branch, 77555, Galveston, TX, USA.
Benjamin B GelmanDepartment of Pathology, University of Texas Medical Branch, 77555, Galveston, TX, USA.
Janice J EndsleyDepartment of Microbiology and Immunology, University of Texas Medical Branch, 77555, Galveston, TX, USA.
Mark A EndsleyDepartment of Microbiology and Immunology, University of Texas Medical Branch, 77555, Galveston, TX, USA. maendsle@utmb.edu.
The University of Texas Medical Branch at Galveston · US

Funding

Vector-pathogen-host interaction and immunopathogenesis of disease progressionZIAAI001344 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SAITO, TAIS B · 2021 to 2025
$8.4M
HIV-induced Defects in Pulmonary Macrophages Exacerbate Mycobacterium Tuberculosis Co-infectionR01HL129881 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ENDSLEY, JANICE J, GELMAN, BENJAMIN B. · 2016 to 2018
$2.1M
HIV-induced Defects in Pulmonary Macrophages Exacerbate Mycobacterium Tuberculosis Co-infectionR56HL129881 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ENDSLEY, JANICE J, GELMAN, BENJAMIN B. · 2015 to 2015
$638k
NHLBI NIH HHS R01 HL129881NHLBI NIH HHS R56 HL129881
6 · The paper itself

Abstract

The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an established model of HIV infection, but defects in immune tissue reconstitution remain a challenge for examining pathology in tissues. We utilized exogenous injection of the human recombinant FMS-like tyrosine kinase 3 ligand (rFLT-3 L) into the hematopoietic stem cell (HSC) cord blood HIS mouse model to significantly expand the total area of lymph node (LN) and the number of circulating human T cells. The results enabled visualization and quantification of HIV infectivity, CD4 T cell depletion and other measures of pathogenesis in the secondary lymphoid tissues of the spleen and LN. Treatment with the Caspase-1/4 inhibitor VX-765 limited CD4

Indexed as

CD4-Positive T-LymphocytesDisease Models, AnimalHIV-1HIV InfectionsAnimalsAnti-Retroviral AgentsCaspase InhibitorsCaspasesHumansLymph NodesLymphoid TissueMiceSpleenViral LoadAnti-Retroviral AgentsCaspase InhibitorsCaspasesCaspase − 1HIV-1Lymphoid tissuePathogenesis

Identifiers

PMID38693565
PMCPMC11064318
OpenAlexW4396535755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.