Evidence map›Paper›PMID 38693486›Full record

ArticleBMC genomics2024

Dynamic evolution of the mTHF gene family associated with primary metabolism across life.

Adam M Rork, Arthi S Bala, Tanya Renner

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam M RorkDepartment of Entomology, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA. rork@purdue.edu.
Arthi S BalaDepartment of Entomology, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
Tanya RennerDepartment of Entomology, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA. tur158@psu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe folate cycle of one-carbon (C1) metabolism, which plays a central role in the biosynthesis of nucleotides and amino acids, demonstrates the significance of metabolic adaptation. We investigated the evolutionary history of the methylenetetrahydrofolate dehydrogenase (mTHF) gene family, one of the main drivers of the folate cycle, across life.

resultsThrough comparative genomic and phylogenetic analyses, we found that several lineages of Archaea lacked domains vital for folate cycle function such as the mTHF catalytic and NAD(P)-binding domains of FolD. Within eukaryotes, the mTHF gene family diversified rapidly. For example, several duplications have been observed in lineages including the Amoebozoa, Opisthokonta, and Viridiplantae. In a common ancestor of Opisthokonta, FolD and FTHFS underwent fusion giving rise to the gene MTHFD1, possessing the domains of both genes.

conclusionsOur evolutionary reconstruction of the mTHF gene family associated with a primary metabolic pathway reveals dynamic evolution, including gene birth-and-death, gene fusion, and potential horizontal gene transfer events and/or amino acid convergence.

Indexed as

Evolution, MolecularMethylenetetrahydrofolate Dehydrogenase (NADP)Multigene FamilyPhylogenyArchaeaEukaryotaGene Transfer, HorizontalMetabolic Networks and PathwaysMethylenetetrahydrofolate Dehydrogenase (NADP)ArchaeaBacteriaEukaryaEvolutionFolate cycleGene familyOne-carbon metabolism

Identifiers

PMID38693486
PMCPMC11064299

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.