Evidence map›Paper›PMID 38693411›Full record

ArticleNature2024

Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling.

Tian-Ci Wang, Binh Khanh Mai, Zheng Zhang, Zhiyu Bo, Jiedong Li, Peng Liu, Yang Yang

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Promiscuity-Guided Enzyme Evolution via Substrate Multiplexed Screening.Angewandte Chemie (International ed. in English) · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Pyridoxal 5'-Phosphate-Dependent Enzymatic Decarboxylative Annulation.Journal of the American Chemical Society · 2026
    Article
  11. Article
  12. Article
  13. Harnessing Photoenzymatic Systems for Intermolecular C-H Fluorination.Angewandte Chemie (International ed. in English) · 2026
    Article
  14. Article
  15. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  16. Designing and Engineering Enzymes for New-to-Nature Photobiocatalysis.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tian-Ci WangDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA.
Binh Khanh MaiDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-8487-1417
Zheng ZhangDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA.
Zhiyu BoDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA.
Jiedong LiDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA.
Peng LiuDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA. pengliu@pitt.edu.ORCID 0000-0002-8188-632X
Yang YangDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA. yang@chem.ucsb.edu.ORCID 0000-0002-4956-2034

Funding

Computational Models for Reactivity and Selectivity in Transition Metal-Catalyzed Olefin FunctionalizationR35GM128779 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peng Liu · 2018 to 2026
$2.9M
An Evolvable Metalloenzyme Platform for Stereoselective Radical BiocatalysisR35GM147387 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Yang Yang · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM128779NIGMS NIH HHS R35 GM147387
6 · The paper itself

Abstract

Photobiocatalysis-where light is used to expand the reactivity of an enzyme-has recently emerged as a powerful strategy to develop chemistries that are new to nature. These systems have shown potential in asymmetric radical reactions that have long eluded small-molecule catalysts

Indexed as

Amino AcidsBiocatalysisOxidative CouplingPhotochemical ProcessesAmino Acids, Branched-ChainDirected Molecular EvolutionFree RadicalsGlycineGlycine HydroxymethyltransferaseIndicators and ReagentsLightPyridoxal PhosphateStereoisomerismAmino AcidsAmino Acids, Branched-ChainFree RadicalsGlycineGlycine HydroxymethyltransferaseIndicators and ReagentsPyridoxal Phosphate

Identifiers

PMID38693411
PMCPMC11299865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.