ArticleNature metabolism2024
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
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42 citing papers in PubMed.
- Exercise-induced protein lactylation: From molecular mechanisms to precision health applications.iScience · 2026Review
- Acute exercise-induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice.Experimental physiology · 2026Article
- Angiogenic behavior of human umbilical vein endothelial cells in hydrogel containing lyophilized powder of decellularized adipose tissue from high-fat diet-fed or exercise-trained rats.Metabolism open · 2026Article
- Hepatic metabolic adaptation to endurance exercise: temporal and sex differences by multiomics integration and validation.Cell communication and signaling : CCS · 2026Article
- Chlorogenic Acid as a Modulator of Adipose Tissue Function and Metabolic Homeostasis: Evidence from Preclinical Studies.Nutrients · 2026Review
- Refinement Measure Using NMR for Subcutaneous Fat Mass Determination in Rats.Animals : an open access journal from MDPI · 2026Article
- Endurance exercise elicits temporal and sexual dimorphic multi-omics remodeling of liver metabolism revealed by MoTrPAC.Cell reports · 2026Article
- Untargeted metabolomics reveals effects of calorie restriction on skeletal muscle in older female and male rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The long non-coding RNA landscape of endurance exercise training.Molecular metabolism · 2026Article
- Subcutaneous White Adipose Tissue Derived from Female Mice Achieves Better Graft Outcomes Through the Involvement of Tregs.Aesthetic plastic surgery · 2026Article
- Influence of Exercise on Proteolysis-Related Markers of Cardiac, Renal, and Endothelial Dysfunction.Cureus · 2026Article
- Sexually distinct multi-omic responses to progressive endurance exercise training in the rat lung.American journal of respiratory cell and molecular biology · 2026Article
- Muscle movement and metabolism: exercise and skeletal muscle as mediators of health-a report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.The American journal of clinical nutrition · 2026Article
- Sex differences in response to a short-term training program intervention in obese adolescents: a plasma metabolomics study.Biology of sex differences · 2026Article
- Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.bioRxiv : the preprint server for biology · 2026Article
- Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise.bioRxiv : the preprint server for biology · 2026Article
- Cognitive impairment caused by compromised hepatic ketogenesis is prevented by endurance exercise.The Journal of physiology · 2026Article
- Ep300-mediated acetylation plasticity in the acetyl-CoA metabolic network drives the protective role of intensive lifestyle intervention in visceral white adipose tissue.Cell communication and signaling : CCS · 2026Article
- Advances in Adipose Tissue Biology.Endocrine reviews · 2026Review
- Obesity and Exercise: New Insights and Perspectives.Endocrine reviews · 2025Review
Corrections and comments
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Authors and funding
27 authors.
Gina M Many *Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID http://orcid.org/0000-0003-4779-1690
James A Sanford *Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID http://orcid.org/0000-0001-7901-5579
Tyler J Sagendorf *Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID http://orcid.org/0000-0003-1552-4870
Zhenxin HouDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-1301-0799
Pasquale NigroSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2918-8356
Katie L WhytockTranslational Research Institute, AdventHealth, Orlando, FL, USA.ORCID http://orcid.org/0000-0003-3486-9452
David AmarDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9719-0837
Tiziana CaputoSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3854-5677
Nicole R GayDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9138-9354
David A GaulSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-9308-1895
Michael F HirshmanSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8728-6379
David Jimenez-MoralesDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4356-6461
Malene E LindholmDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5763-7833
Michael J MuehlbauerDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.
Maria VamviniSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1532-1689
Bryan C BergmanDivision of Endocrinology, Diabetes, and Metabolism, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-9561-1052
Facundo M FernándezSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-0302-2534
Laurie J GoodyearSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6299-2928
Andrea L HevenerDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1508-4377
Eric A OrtlundDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-8855-3029
Lauren M SparksTranslational Research Institute, AdventHealth, Orlando, FL, USA.ORCID http://orcid.org/0000-0002-8724-6016
Ashley XiaNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Joshua N AdkinsBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Joshua.Adkins@pnnl.gov.ORCID http://orcid.org/0000-0003-0399-0700
Sue C BodineAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. bodines@omrf.org.ORCID http://orcid.org/0000-0002-5742-9145
Christopher B NewgardDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA. chris.newgard@duke.edu.ORCID http://orcid.org/0000-0002-1293-691X
Simon SchenkDepartment of Orthopaedic Surgery, School of Medicine, University of California San Diego, La Jolla, CA, USA. sschenk@ucsd.edu.ORCID http://orcid.org/0000-0002-8224-3203
MoTrPAC Study Group
Funding
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MMoTrPAC Supplemental Funding for MillerU24AR071113 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jon Peter Durda, Karyn A Esser · 2017 to 2026
$28.8MPAGES: Physical Activity Genomics, Epigenomics/transcriptomics SiteU24DK112331 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STUART C. SEALFON, Martin John Walsh · 2017 to 2026
$18.5MStanford/Salk MoTrPAC Site for Genomes, Epigenomes and TranscriptomesU24DK112348 · NIDDK · STANFORD UNIVERSITY · PI Stephen Montgomery, MICHAEL P. SNYDER · 2017 to 2026
$18.4MMolecular Transducers of Physical Activity Consortium Adult Clinical CenterU01AR071130 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUSI, NICOLAS, RASMUSSEN, BLAKE B · 2017 to 2024
$17.7MProMoTr: A Proteomics Center for MoTrPACU24DK112349 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI Joshua N. Adkins · 2017 to 2026
$17.5MThe Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical CenterU01AR071133 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUFORD, THOMAS W, GOODPASTER, BRET H · 2017 to 2024
$16.7MA Biochemical Roadmap of Exercise Signaling - Pilot Project for MoTrPAC ConsortiumU24DK112340 · NIDDK · BROAD INSTITUTE, INC. · PI STEVEN A CARR, Clary B Clish · 2017 to 2026
$16.2MMoTrPAC DXA Quality ControlU01AR071128 · NIAMS · DUKE UNIVERSITY · PI HOUMARD, JOSEPH A, KRAUS, WILLIAM E · 2017 to 2025
$15.2MMolecular Transducers of Physical Activity Consortium - Colorado Clinical CenterU01AR071124 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2017 to 2024
$14.5MSan Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ROBERT A CLARK · 2015 to 2026
$14.1MStanford MoTrPAC Bioinformatics CenterU24OD026629 · OD · STANFORD UNIVERSITY · PI ASHLEY, EUAN A, WHEELER, MATTHEW THOMAS · 2018 to 2023
$13.9MNHGRI NIH HHS T32 HG000044NHLBI NIH HHS F32 HL154711NIAMS NIH HHS U01 AR071124NIAMS NIH HHS U01 AR071128NIAMS NIH HHS U01 AR071130NIAMS NIH HHS U01 AR071133NIAMS NIH HHS U01 AR071150NIAMS NIH HHS U01 AR071158NIAMS NIH HHS U01 AR071160NIAMS NIH HHS U24 AR071113NIA NIH HHS P30 AG044271NIA NIH HHS U01 AG055133NIA NIH HHS U01 AG055135NIA NIH HHS U01 AG055137NIDDK NIH HHS F32 DK126432NIDDK NIH HHS U24 DK112326NIDDK NIH HHS U24 DK112331NIDDK NIH HHS U24 DK112340NIDDK NIH HHS U24 DK112341NIDDK NIH HHS U24 DK112342NIDDK NIH HHS U24 DK112348NIDDK NIH HHS U24 DK112349NIH HHS U24 OD026629U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U24DK112340U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U24DK112341U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U24DK112349U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U01AG055133U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U01AG055135
Abstract
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.
Indexed as
Adipose Tissue, WhitePhysical Conditioning, AnimalSex CharacteristicsSubcutaneous FatAdipogenesisAnimalsFemaleMaleMultiomicsRatsRats, Sprague-Dawley
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