Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
32 authors at 6 institutions in 2 countries.
Kira Flinkenflügel *Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Marius Gruber *Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0003-2177-7161
Katharina ThielInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Alexandra WinterInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0003-3759-1425
Janik GoltermannInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0003-3087-1002
Paula UsemannDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Katharina BroschDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID 0000-0002-0526-8095
Frederike SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Florian Thomas-OdenthalDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID 0000-0003-4912-8307
Adrian WroblewskiDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID 0000-0002-0371-7686
Julia-Katharina PfarrDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Friederike S DavidInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID 0000-0001-9521-5669
Eva C BeinsInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-7779-0210
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0001-8718-0128
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0001-6541-3795
Elisabeth J LeehrInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID 0000-0002-9264-5003
Katharina DohmInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Jochen BauerDepartment of Radiology, University of Münster, Münster, Germany.ORCID 0000-0001-9345-2126
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-1876-6368
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-8770-2464
Hamidreza JamalabadiDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID 0000-0003-2485-2374
Benjamin StraubeDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID 0000-0002-9837-0944
Nina AlexanderDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Andreas JansenDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-1571-1468
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-5236-6149
Igor NenadićDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Martijn P van den HeuvelConnectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.ORCID 0000-0003-1570-1195
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Jonathan ReppleInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany. dannlow@uni-muenster.de.ORCID 0000-0002-0623-3759
Philipps University of Marburg · DEUniversity of Münster · DEUniversity of Bonn · DEGoethe University Frankfurt · DEHeidelberg University · DEAmsterdam Neuroscience · NL
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) DA1151/5-1, DA1151/5-2, DA1151/11‑1 DA1151/6-1Deutsche Forschungsgemeinschaft (German Research Foundation) HA7070/2-2, HA7070/3, HA7070/4Deutsche Forschungsgemeinschaft (German Research Foundation) JA 1890/7-1, JA 1890/7-2Deutsche Forschungsgemeinschaft (German Research Foundation) KI 588/14-1, KI 588/14-2, KI 588/22-1Deutsche Forschungsgemeinschaft (German Research Foundation) NO 246/10-1, NO 246/10-2Deutsche Forschungsgemeinschaft (German Research Foundation) RI 908/11-1, RI 908/11-2Deutsche Forschungsgemeinschaft (German Research Foundation) STR 1146/18-1Deutsche Forschungsgemeinschaft (German Research Foundation) WI 3439/3-1, WI 3439/3-2EPA EP-C-16-015Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) ERC-COG 101001062, VIDI-452-16-015
6 · The paper itself
Abstract
Reduced processing speed is a core deficit in major depressive disorder (MDD) and has been linked to altered structural brain network connectivity. Ample evidence highlights the involvement of genetic-immunological processes in MDD and specific depressive symptoms. Here, we extended these findings by examining associations between polygenic scores for tumor necrosis factor-α blood levels (TNF-α PGS), structural brain connectivity, and processing speed in a large sample of MDD patients. Processing speed performance of n = 284 acutely depressed, n = 177 partially and n = 198 fully remitted patients, and n = 743 healthy controls (HC) was estimated based on five neuropsychological tests. Network-based statistic was used to identify a brain network associated with processing speed. We employed general linear models to examine the association between TNF-α PGS and processing speed. We investigated whether network connectivity mediates the association between TNF-α PGS and processing speed. We identified a structural network positively associated with processing speed in the whole sample. We observed a significant negative association between TNF-α PGS and processing speed in acutely depressed patients, whereas no association was found in remitted patients and HC. The mediation analysis revealed that brain connectivity partially mediated the association between TNF-α PGS and processing speed in acute MDD. The present study provides evidence that TNF-α PGS is associated with decreased processing speed exclusively in patients with acute depression. This association was partially mediated by structural brain connectivity. Using multimodal data, the current findings advance our understanding of cognitive dysfunction in MDD and highlight the involvement of genetic-immunological processes in its pathomechanisms.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression. · full record | OpenQuestion