ArticleNature2024
Geographic variation of mutagenic exposures in kidney cancer genomes.
Open access · hybridAbstract readComparative Study
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
17.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations.Nature communications · 2026Pooled it
- Proteomic Analysis Identifies Potential Biomarkers of ELOC -Mutated Renal Cell Carcinoma.The American journal of surgical pathology · 2026Article
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- Centralized processing of frozen tumor tissues for global cancer genomics.Nature protocols · 2026Review
- Identification and validation of a previously missed mutational signature in colorectal cancer.Nature communications · 2026Article
- Early replication fragile sites are associated with cancer-related CNVs and SNVs in human embryonic stem cells.Stem cell reports · 2026Article
- A single chromosome 3p break initiates clear cell renal cell carcinoma evolution.bioRxiv : the preprint server for biology · 2026Article
- Global patterns and trends in kidney cancer incidence and mortality.International journal of cancer · 2026Article
- Engineered artificial antigen-presenting cells for tumor immunotherapy: Design strategies, clinical applications, and translational challenges.Materials today. Bio · 2026Review
- PULPO: pipeline of understanding large-scale patterns of oncogenomic signatures.Bioinformatics (Oxford, England) · 2026Article
- Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome.Nature chemical biology · 2026Article
- Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting.Nature communications · 2026Article
- Tumour promotion through the lens of evolution.Nature · 2026Review
- Disparities in Cancer and Cardiovascular Disease Mortality Among Asian Americans Diagnosed with Urologic Cancer.Journal of racial and ethnic health disparities · 2026Article
- SigRescueR: a pan-system framework for noise correction and mutational signature identification across sequencing platforms.Briefings in bioinformatics · 2026Article
- High incidence of intrahepatic cholangiocarcinoma in end-stage renal disease patients in Taiwan: analysis of a nationwide database with molecular insight of aristolochic acid exposure.Virchows Archiv : an international journal of pathology · 2026Article
- Article
- Genome-wide analysis of somatic noncoding mutation patterns and mitochondrial heteroplasmic shift in type B1 and B2 thymomas.The Journal of pathology · 2026Article
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- APOBEC3B enhances the efficacy of PARP inhibitors in elimination of ovarian cancer stem cell.Scientific reports · 2026Article
Corrections and comments
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Authors and funding
79 authors at 20 institutions in 20 countries.
Sergey Senkin *Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID http://orcid.org/0000-0001-5848-005X
Sarah Moody *Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-4904-1041
Marcos Díaz-GayDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0658-0467
Behnoush Abedi-ArdekaniGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Thomas CattiauxGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID http://orcid.org/0000-0002-4826-7965
Aida Ferreiro-IglesiasGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Jingwei WangCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-0201-2369
Stephen FitzgeraldCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-0585-4833
Mariya KazachkovaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Raviteja VangaraDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Anh Phuong LeCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-5495-6425
Erik N BergstromDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Azhar KhandekarDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Burçak OtluDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Saamin CheemaCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-5297-2042
Calli LatimerCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Emily ThomasCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Joshua Ronald AtkinsCancer Epidemiology Unit, The Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Karl Smith-ByrneCancer Epidemiology Unit, The Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1932-7463
Ricardo Cortez Cardoso PenhaGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Christine CarreiraEvidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Priscilia ChopardGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Valérie GaborieauGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Pekka Keski-RahkonenNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID http://orcid.org/0000-0001-9437-3040
David JonesCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-0407-0386
Jon W TeagueCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Sophie FerlicotService d'Anatomie Pathologique, Assistance Publique-Hôpitaux de Paris, Univeristé Paris-Saclay, Le Kremlin-Bicêtre, France.
Mojgan AsgariOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Surasak SangkhathatTranslational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
Worapat AttawettayanonDivision of Urology, Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.
Sonata JarmalaiteLaboratory of Genetic Diagnostic, National Cancer Institute, Vilnius, Lithuania.
Rasa SabaliauskaiteLaboratory of Genetic Diagnostic, National Cancer Institute, Vilnius, Lithuania.
Tatsuhiro ShibataLaboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.
Akihiko FukagawaDivision of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan.
Dana MatesOccupational Health and Toxicology Department, National Center for Environmental Risk Monitoring, National Institute of Public Health, Bucharest, Romania.
Viorel JingaUrology Department, Carol Davila University of Medicine and Pharmacy, Prof. Dr. Th. Burghele Clinical Hospital, Bucharest, Romania.
Stefan RascuUrology Department, Carol Davila University of Medicine and Pharmacy, Prof. Dr. Th. Burghele Clinical Hospital, Bucharest, Romania.
Mirjana MijuskovicClinic of Nephrology, Faculty of Medicine, Military Medical Academy, Belgrade, Serbia.
Slavisa SavicDepartment of Urology, University Hospital Dr D. Misovic Clinical Center, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-3635-7437
Sasa MilosavljevicInternational Organization for Cancer Prevention and Research, Belgrade, Serbia.
John M S BartlettCancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Monique AlbertCentre for Biodiversity Genomics, University of Guelph, Guelph, Ontario, Canada.
Larry PhouthavongsyOntario Tumour Bank, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0007-6853-7233
Patricia Ashton-ProllaExperimental Research Center, Genomic Medicine Laboratory, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Mariana R BottonTransplant Immunology and Personalized Medicine Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0002-0509-9199
Brasil Silva NetoService of Urology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Stephania Martins BezerraDepartment of Anatomic Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Maria Paula CuradoDepartment of Epidemiology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Stênio de Cássio ZequiDepartment of Urology, A. C. Camargo Cancer Center, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-1897-8085
Rui Manuel ReisMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
Eliney Ferreira FariaFaculdade Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil.
Nei Soares de MenezesDepartment of Pathology, Barretos Cancer Hospital, Barretos, Brazil.
Renata Spagnoli FerrariDepartment of Urology, Barretos Cancer Hospital, Barretos, Brazil.
Rosamonde E BanksLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-0042-8715
Naveen S VasudevLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
David ZaridzeDepartment of Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Anush MukeriyaDepartment of Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Oxana ShanginaDepartment of Clinical Epidemiology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Vsevolod MatveevDepartment of Urology, N. N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.ORCID http://orcid.org/0000-0001-7748-9527
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-0494-2620
Marie NavratilovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Ivana HolcatovaInstitute of Public Health and Preventive Medicine, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Anna HornakovaInstitute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-1024-8056
Vladimir JanoutFaculty of Health Sciences, Palacky University, Olomouc, Czech Republic.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Per Magne UelandBevital AS, Bergen, Norway.
Mattias JohanssonGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
James McKayGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Ghislaine SceloObservational and Pragmatic Research Institute Pte Ltd, Singapore, Singapore.
Estelle ChanudetDepartment of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands.
Laura HumphreysCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.
Ana Carolina de CarvalhoGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Sandra PerdomoGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3596-4515
Michael R StrattonCancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-6035-153X
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. brennanp@iarc.who.int.ORCID http://orcid.org/0000-0002-0518-8714
Centre international de recherche sur le cancer · FRWellcome Sanger Institute · GBUniversity of California San Diego · USHospital de Câncer de Barretos · BRRussian Cancer Research Center NN Blokhin · RUAC Camargo Hospital · BRNational Cancer Institute · USCarol Davila University of Medicine and Pharmacy · ROCharles University · CZMasaryk Memorial Cancer Institute · CZOntario Institute for Cancer Research · CAPrince of Songkla University · THThe University of Tokyo · JPUniversidade Federal do Rio Grande do Sul · BRUniversity of Leeds · GBUniversity of Oxford · GBAssistance Publique – Hôpitaux de Paris · FRBevital (Norway) · NOEdinburgh Cancer Research · GBHospital de Clínicas de Porto Alegre · BR
Funding
Predoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5MMapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1MNCI NIH HHS T32 CA067754NCI NIH HHS U01 CA290479Wellcome TrustWorld Health Organization 001
Abstract
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden
Indexed as
Carcinoma, Renal CellEnvironmental ExposureGeographyKidney NeoplasmsMutagensMutationAristolochic AcidsFemaleGenome, HumanGenomicsHumansHypertensionIncidenceJapanMaleObesityAristolochic AcidsMutagens
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