Evidence map›Paper›PMID 38693258›Full record

ArticleNature2024

Mitochondrial transfer mediates endothelial cell engraftment through mitophagy.

Ruei-Zeng Lin, Gwang-Bum Im, Allen Chilun Luo, Yonglin Zhu, Xuechong Hong, Joseph Neumeyer, Hong-Wen Tang, Norbert Perrimon, Juan M Melero-Martin

Open access · greenAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 3 pooled it
68.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 3 syntheses or guidelines pooled it, 178 citations in OpenAlex.

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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ruei-Zeng LinDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.
Gwang-Bum ImDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.
Allen Chilun LuoDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6995-6586
Yonglin ZhuDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6932-2946
Xuechong HongDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.
Joseph NeumeyerDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.
Hong-Wen TangDepartment of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8347-9891
Norbert PerrimonDepartment of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7542-472X
Juan M Melero-MartinDepartment of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA. juan.meleromartin@childrens.harvard.edu.ORCID 0000-0002-4689-8149
Boston Children's Hospital · USHoward Hughes Medical Institute · US

Funding

Vascular networks genetically engineered for protein drug deliveryR01HL128452 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI MELERO-MARTIN, JUAN M, WANG, BO · 2015 to 2024
$4.8M
Enhancing endothelial cell engraftment via transplantation of exogenous mitochondriaR01HL152133 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Juan M Melero-Martin · 2021 to 2026
$3.1M
Human endothelial cell regulation of ossificationR01AR080086 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI Juan M Melero-Martin · 2022 to 2026
$2.1M
NHLBI NIH HHS R01 HL128452NHLBI NIH HHS R01 HL152133NIAMS NIH HHS R01 AR080086
6 · The paper itself

Abstract

Ischaemic diseases such as critical limb ischaemia and myocardial infarction affect millions of people worldwide

Indexed as

Cell- and Tissue-Based TherapyEndothelial CellsIschemiaMitochondriaMitophagyAnimalsAutophagosomesEnergy MetabolismHumansHuman Umbilical Vein Endothelial CellsMaleMesenchymal Stem CellsMiceMice, NudeProtein KinasesPTEN-Induced Putative Kinaseparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein Ligases

Identifiers

PMID38693258
PMCPMC11574736
OpenAlexW4396544387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.