ArticleNature2024
Structural and molecular basis of choline uptake into the brain by FLVCR2.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Heme as a versatile signaling molecule: Coordinating mitochondrial metabolism with global cellular responses.The Journal of biological chemistry · 2026Review
- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- A conserved vesicular circuit enables metabolic adaptation and maintains systemic heme homeostasis.bioRxiv : the preprint server for biology · 2026Article
- FLVCR2 Regulation of Intracellular Heme Modulates Vascular Tip/Stalk Specification During Retinal Angiogenesis.Investigative ophthalmology & visual science · 2026Article
- Structural and biochemical comparison of the FLVCR and CTL membrane protein families in eukaryotes.Life science alliance · 2026Article
- More than a ring: the emerging role of heme in angiogenesis.Cell communication and signaling : CCS · 2026Review
- Structural insights into a conserved mechanism of choline translocation through CHT.Science advances · 2026Article
- Mechanistic basis of teichoic acid transport by a gatekeeper flippase.Nature communications · 2026Article
- PMPCylated liposomes in drug delivery and beyond.Materials today. Bio · 2026Review
- Development of the blood-brain barrier.Development (Cambridge, England) · 2026Review
- Optimization of Ionic Liquid Based NLC for Nose-To-Brain Delivery of Tetrabenazine Hydrochloride.AAPS PharmSciTech · 2026Article
- The regulatory roles and therapeutic strategies of the solute carrier transporters in cancer metabolism.NPJ precision oncology · 2026Review
- Micronutrient balance and brain function: neuropsychological, metabolic, and clinical interactions.Frontiers in molecular biosciences · 2026Review
- Proteomic profiling reveals age-related changes in transporter proteins in the human blood-brain barrier.Scientific reports · 2025Article
- Article
- A novel ultrasound-responsive cluster bomb system for efficient siRNA delivery in brain.Ultrasonics sonochemistry · 2025Article
- Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH.Nature communications · 2025Article
- Endothelial mitochondria in the blood-brain barrier.Fluids and barriers of the CNS · 2025Review
- Choline-An Essential Nutrient with Health Benefits and a Signaling Molecule.International journal of molecular sciences · 2025Review
Corrections and comments
- Update of
Authors and funding
23 authors at 8 institutions in 3 countries.
Rosemary J Cater *Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA. r.cater@uq.edu.au.ORCID 0000-0003-4503-002X
Dibyanti Mukherjee *Department of Pediatrics, Neonatal Brain Research Institute, University of California San Francisco, San Francisco, CA, USA.
Eva Gil-IturbeDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4046-5756
Satchal K ErramilliDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-8694-7681
Ting ChenDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Katie KooDepartment of Pediatrics, Neonatal Brain Research Institute, University of California San Francisco, San Francisco, CA, USA.
Nicolás SantanderInstituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile.ORCID 0000-0001-8919-833X
Andrew ReckersDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-7567-8540
Brian KlossDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Tomasz GawdaDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7906-0097
Brendon C ChoyDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Zhening ZhangCryo-Electron Microscopy Center, Columbia University, New York, NY, USA.
Aditya KatewaDepartment of Pediatrics, Neonatal Brain Research Institute, University of California San Francisco, San Francisco, CA, USA.
Amara LarpthaveesarpDepartment of Pediatrics, Neonatal Brain Research Institute, University of California San Francisco, San Francisco, CA, USA.
Eric J HuangDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5381-3801
Scott W J MooneyBurke Neurological Institute, White Plains, NY, USA.
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Sook Wah YeeDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-8121-8746
Kathleen M GiacominiDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0001-8041-5430
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-3174-9359
Matthias QuickDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Thomas ArnoldDepartment of Pediatrics, Neonatal Brain Research Institute, University of California San Francisco, San Francisco, CA, USA. thomas.arnold@ucsf.edu.ORCID 0000-0002-7310-5597
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA. fm123@cumc.columbia.edu.ORCID 0000-0003-3293-2200
University of California, San Francisco · USColumbia University · USColumbia University Irving Medical Center · USUniversity of Chicago · USBurke Medical Research Institute · USSan Francisco VA Medical Center · USThe University of Queensland · AUUniversity of O'Higgins · CL
Funding
Training (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1MChaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0MStructural basis of integral membrane enzyme functionR35GM132120 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Filippo Mancia · 2019 to 2026
$3.7MDefective heme transport in the development of congenital hydrocephalusR01NS123168 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD, THOMAS DARMODY · 2021 to 2025
$3.1MStructure-Guiding Tools to Study the Role of Choline in the Development of Congenital HydrocephalusR01NS142590 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Thomas Darmody Arnold · 2025 to 2026
$1.3MMolecular Tools to Study FLVCR2-mediated Heme Transport in Brain AngiogenesisR21NS129105 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD, THOMAS DARMODY, MANCIA, FILIPPO · 2022 to 2022
$464kMolecular mechanisms underlying heme transport at the blood-brain barrier and its role in angiogenesisK99HL166866 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CATER, ROSEMARY JANE · 2023 to 2023
$161kNHLBI NIH HHS K99 HL166866NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM117372NIGMS NIH HHS R35 GM132120NINDS NIH HHS R01 NS123168NINDS NIH HHS R01 NS142590NINDS NIH HHS R21 NS129105
Abstract
Choline is an essential nutrient that the human body needs in vast quantities for cell membrane synthesis, epigenetic modification and neurotransmission. The brain has a particularly high demand for choline, but how it enters the brain remains unknown
Indexed as
BrainCholineMembrane Transport ProteinsAnimalsBiological TransportBlood-Brain BarrierCryoelectron MicroscopyFemaleHumansIn Vitro TechniquesMaleMiceMiddle AgedModels, MolecularReceptors, VirusCholineFLVCR2 protein, humanMembrane Transport ProteinsReceptors, Virus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.