Evidence map›Paper›PMID 38693246›Full record

ReviewNPJ microgravity2024

How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Craig R G Willis, Marco Calvaruso, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Eugénie Carnero-Diaz, Sara Castiglioni and 46 more

Abstract readReview
In one paragraph

Review in NPJ microgravity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Multiscale Modeling and Systems Biology in Microgravity Investigations.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Craig R G Willis *School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford, Bradford, United Kingdom.
Marco Calvaruso *Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Cefalù, Italy.
Debora AngeloniInstitute of Biorobotics, Scuola Superiore Sant'Anna, Pisa, Italy.
Sarah BaatoutLaboratory of Radiobiology, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgium.ORCID http://orcid.org/0000-0001-8110-751X
Alexandra BenchouaISTEM, CECS, AFM-Téléthon, Corbeil-Essonnes, France.
Juergen Bereiter-HahnInstitute for Cell and Neurobiol. Goethe University Frankfurt am Main, Frankfurt am Main, Germany.
Daniele BottaiDepartment of Pharmaceutical Sciences, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-7951-9512
Judith-Irina BuchheimLaboratory "Translational Research, Stress & Immunity", LMU University Hospital Munich, Munich, Germany.
Eugénie Carnero-DiazInstitute Systematic, Evolution, Biodiversity, Sorbonne University, NMNH, CNRS, EPHE, UA, Paris, France.
Sara CastiglioniDepartment of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Duccio CavalieriDepartment of Biology, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0001-6426-5719
Gabriele CeccarelliDepartment of Public Health, Experimental Medicine and Forensic, University of Pavia, Pavia, Italy.
Alexander ChoukerLaboratory "Translational Research, Stress & Immunity", LMU University Hospital Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-0133-4104
Francesca CialdaiASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence, Florence, Italy.
Gianni CiofaniSmart Bio-Interfaces, Istituto Italiano di Tecnologia, 56025, Pontedera, PI, Italy.ORCID http://orcid.org/0000-0003-1192-3647
Giuseppe CoppolaInstitue of Applied Science and Intelligent Sistems - CNR, Naples, Italy.
Gabriella CusellaDepartment of Public Health, Experimental Medicine and Forensic, University of Pavia, Pavia, Italy.
Andrea Degl'InnocentiSmart Bio-Interfaces, Istituto Italiano di Tecnologia, 56025, Pontedera, PI, Italy.
Jean-Francois DesaphyDepartment of Precision and Regenerative Medicine, University of Bari "Aldo Moro", Bari, Italy.ORCID http://orcid.org/0000-0001-8816-9369
Jean-Pol FrippiatStress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine, Nancy, France.ORCID http://orcid.org/0000-0002-4027-6269
Michael GelinskyCentre for Translational Bone, Joint & Soft Tissue Research, TU Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-9075-5121
Giada GenchiSmart Bio-Interfaces, Istituto Italiano di Tecnologia, 56025, Pontedera, PI, Italy.
Maria GranoDepartment of Precision and Regenerative Medicine, University of Bari "Aldo Moro", Bari, Italy.
Daniela GrimmDepartment of Microgravity and Translational Regenerative Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.ORCID http://orcid.org/0000-0002-4991-3105
Alain GuignandonSAINBIOSE, INSERM U1059, Université Jean Monnet, F-42000, Saint-Etienne, France.
Raúl HerranzCentro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-0246-9449
Christine HellwegRadiation Biology Dept., Inst. of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.ORCID http://orcid.org/0000-0002-2223-3580
Carlo Saverio IorioCREST-ATM, Université libre de Bruxelles, Brussels, Belgium.ORCID http://orcid.org/0000-0003-0952-0064
Thodoris KarapantsiosFaculty of Chemistry, Aristotle Univeristy of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0001-6641-3359
Jack van LoonAmsterdam University Medical Center, ACTA/VU, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0001-9051-6016
Matteo LulliDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0002-8528-4094
Jeanette MaierDepartment of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Jos MaldaDepartment of Orthopaedics, Univ. Med. Center Utrecht & Dept. Clinical Sciences, Utrecht Univ, Utrecht, The Netherlands.
Emina MamacaEuropean and International Affairs Dept, Ifremer centre Bretagne, Plouzané, France.
Lucia MorbidelliDepartment of Life Sciences, Univ. of Siena, Siena, Italy.
Andreas OstermanMax von Pettenkofer Institute, Virology, LMU Munich & DZIF, Partner Site Munich, Munich, Germany.
Aleksandr Ovsianikov3D Printing and Biofabrication, Inst. Materials Science and Technology, TU Wien, Vienna, Austria.ORCID http://orcid.org/0000-0001-5846-0198
Francesco PampaloniBuchmann Inst. for Molecular Life Sciences, Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0003-4357-7320
Elizabeth PavezlorieLudwig Boltzmann Inst. for Traumatology, Res. Center in Cooperation with AUVA, Vienna, Austria.
Veronica Pereda-CamposGSBMS/URU EVOLSAN - Medecine Evolutive, Université Paul Sabatier Toulouse III, Toulouse, France.
Cyrille PrzybylaMARBEC, Univ Montpellier, CNRS, Ifremer, IRD, Palavas les Flots, France.
Petra RettbergDLR, Institute of Aerospace Medicine, Research Group Astrobiology, Köln, Germany.ORCID http://orcid.org/0000-0003-4439-2395
Angela Maria RizzoDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-8582-0432
Kate Robson-BrownDepartment of Engineering Mathematics, and Dept of Anthropology and Archaeology, University of Bristol, Bristol, UK.
Leonardo RossiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Giorgio RussoInstitute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Cefalù, Italy.
Alessandra SalvettiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Chiara RisalitiASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0003-1695-0548
Daniela SantucciCenter for Behavioural Sciences and Mental Health, Ist. Superiore Sanità, Rome, Italy.ORCID http://orcid.org/0000-0002-4619-1290
Matthias SperlDLR-MP, Cologne, Germany.ORCID http://orcid.org/0000-0001-9525-0368
Kevin TaburyLaboratory of Radiobiology, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgium.ORCID http://orcid.org/0000-0002-8004-3718
Sara TavellaIRCCS Ospedale Policlinico San Martino and University of Genoa, DIMES, Genoa, Italy.ORCID http://orcid.org/0000-0003-1478-4910
Christiane ThielemannBioMEMS Lab, University of Applied Sciences Aschaffenburg, Aschaffenburg, Germany.ORCID http://orcid.org/0000-0002-9814-4744
Ronnie WillaertResearch Group NAMI and NANO, Vrije Universiteit Brussels, Brussels, Belgium.ORCID http://orcid.org/0000-0002-5400-7019
Monica MoniciASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence, Florence, Italy.ORCID http://orcid.org/0000-0001-6678-9241
Nathaniel J SzewczykHeritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA. szewczyk@ohio.edu.ORCID http://orcid.org/0000-0003-4425-9746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, "Biology in Space and Analogue Environments", focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: "How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?" The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Identifiers

PMID38693246
PMCPMC11063135

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.