Evidence map›Paper›PMID 38693149›Full record

ArticleNature communications2024

Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer.

Laila Sara Arroyo Mühr, Andrea Gini, Emel Yilmaz, Sadaf S Hassan, Camilla Lagheden, Emilie Hultin, Ainhoa Garcia Serrano, Agustin E Ure, Helena Andersson, Roxana Merino and 3 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04910802 phase4recruitingnot on this map

Concomitant HPV Vaccination and HPV Screening for Rapid Elimination of HPV Infection and Cervical Cancer in Sweden

TypeinterventionalSponsorMiriam ElfströmRan2021 to 2027Enrolled150,000ConditionsHPV Infection, CIN 2/3, Cervical CancerArmsGardasil9
NCT07314307 phase4active not recruitingnot on this map

Vaccine Effectiveness of One Dose of the Nonavalent Human Papillomavirus (HPV) Vaccine Among Young-adult Women in Sweden Among Women Participating in a Clinical Trial of Concomitant HPV Vaccination and Screening

TypeinterventionalSponsorKarolinska InstitutetRan2021 to 2028Enrolled150,000ConditionsIncident HPV16, 18, 31, 33, 45, 52 or 58 InfectionArmsGardasil 9 2 dose regimen
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  16. Natural history of liver fluke infection underpins epidemiological patterns of biliary cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Laila Sara Arroyo MührCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2498-5206
Andrea GiniInternational Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention and Infections Branch, Lyon, France.ORCID http://orcid.org/0000-0002-7696-0580
Emel YilmazCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.
Sadaf S HassanCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.
Camilla LaghedenCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.
Emilie HultinCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2169-0840
Ainhoa Garcia SerranoCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1763-4053
Agustin E UreCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.
Helena AnderssonCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.
Roxana MerinoCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8939-0003
K Miriam ElfströmCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden.
Iacopo BaussanoInternational Agency for Research on Cancer (IARC/WHO), Early Detection, Prevention and Infections Branch, Lyon, France.
Joakim DillnerCenter for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital, F56, Stockholm, Sweden. Joakim.dillner@ki.se.ORCID http://orcid.org/0000-0001-8588-6506
Karolinska University Hospital · SECentre international de recherche sur le cancer · FR

Funding

Cancerfonden (Swedish Cancer Society) 201198PjF01HCancerfonden (Swedish Cancer Society) 201199UsF02HEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 847845Vetenskapsrådet (Swedish Research Council) 2021-01228World Health Organization 001
6 · The paper itself

Abstract

HPV vaccination with concomitant HPV-based screening of young women has been proposed for faster cervical cancer elimination. We describe the baseline results of a population-based trial of this strategy to reduce the incidence of HPV. All 89,547 women born 1994-1999 and resident in the capital region of Sweden were personally invited to concomitant HPV vaccination and HPV screening with 26,125 women (29.2%) enrolled between 2021-05-03 and 2022-12-31. Baseline HPV genotyping of cervical samples from the study participants finds, compared to pre-vaccination prevalences, a strong decline of HPV16 and 18 in birth cohorts previously offered vaccination, some decline for cross-protected HPV types but no decline for HPV types not targeted by vaccines. Our dynamic transmission modelling predicts that the trial could reduce the incidence of high-risk HPV infections among the 1994-1998 cohorts by 62-64% in 3 years. Baseline results are prevalences of HPV infection, validated transmission model projections, and power estimates for evaluating HPV incidence reductions at follow-up (+/-0.1% with 99.9% confidence). In conclusion, concomitant HPV vaccination and HPV screening appears to be a realistic option for faster cervical cancer elimination. Clinicaltrials.gov identifier: NCT04910802; EudraCT number: 2020-001169-34.

Indexed as

Papillomavirus InfectionsPapillomavirus VaccinesUterine Cervical NeoplasmsAdolescentAdultEarly Detection of CancerFemaleHuman papillomavirus 16Human papillomavirus 18Human Papillomavirus VirusesHumansIncidenceMass ScreeningMiddle AgedPrevalenceSwedenPapillomavirus Vaccines

Identifiers

PMID38693149
PMCPMC11063066
OpenAlexW4396547245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.