ArticleJournal of psychiatry & neuroscience : JPN
Disproportionate neuroanatomical effects of
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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors at 2 institutions in 3 countries.
Daniel HoopsFrom the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores).
Yohan YeeFrom the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores).
Christopher HammillFrom the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores).
Sammi WongFrom the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores).
Colleen ManittFrom the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores).
Barry J BedellFrom the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores).
Lindsay CahillFrom the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores).
Jason P LerchFrom the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores).
Cecilia Flores *From the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores) cecilia.flores@mcgill.ca john.sled@sickkids.ca.
John G Sled *From the Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ont. (Hoops, Yee, Hammill, Wong, Lerch, Sled); the Department of Medical Biophysics, University of Toronto, Ont. (Hoops, Yee, Lerch, Sled); the Department of Psychiatry, McGill University, Montréal, Que. (Hoops, Flores); the Douglas Mental Health University Institute, Montréal, Que. (Hoops, Manitt, Flores); the Department of Chemistry, Memorial University, St. John's, N.L. (Hoops, Cahill); the Department of Neurology and Neurosurgery, McGill University, Montréal, Que. (Bedell, Flores); the Wellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, U.K. (Lerch); the Ludmer Centre for Neuroinformatics & Mental Health, McGill University, Montréal, Que. (Flores) cecilia.flores@mcgill.ca john.sled@sickkids.ca.
University of Toronto · CAMemorial University of Newfoundland · CA
Funding
Amphetamine in adolescence disrupts frontal cortex developmentR01DA037911 · NIDA · MCGILL UNIVERSITY · PI FLORES, CECILIA · 2015 to 2024
$2.5MCIHRNIDA NIH HHS R01 DA037911
Abstract
backgroundCritical adolescent neural refinement is controlled by the DCC (deleted in colorectal cancer) protein, a receptor for the netrin-1 guidance cue. We sought to describe the effects of reduced
methodsWe examined neuronal connectivity, structural covariance, and molecular processes in a
resultsWe included 11 LIMITATIONS: Our study involved a single sex (males) at only 2 ages.
conclusionThe neuroanatomical phenotype of
Indexed as
BrainDCC ReceptorDopamineHaploinsufficiencyAge FactorsAgingAnimalsFemaleGene ExpressionMaleMiceMice, Inbred C57BLNeural PathwaysDcc protein, mouseDCC ReceptorDopamine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.