Evidence map›Paper›PMID 38692692›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Altered effective connectivity among face-processing systems in major depressive disorder.

Fangrui Sheng, Yun Wang, Ruinan Li, Xiaoya Li, Xiongying Chen, Zhifang Zhang, Rui Liu, Ling Zhang, Yuan Zhou, Gang Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Fangrui ShengFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou).
Yun WangFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou).
Ruinan LiFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou).
Xiaoya LiFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou).
Xiongying ChenFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou).
Zhifang ZhangFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou).
Rui LiuFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou).
Ling ZhangFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou) 13661341082@163.com zhouyuan@psych.ac.cn gangwangdoc@ccmu.edu.cn.
Yuan ZhouFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou) 13661341082@163.com zhouyuan@psych.ac.cn gangwangdoc@ccmu.edu.cn.
Gang WangFrom the Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China (Sheng, Wang, R. Li, X. Li, Chen, Z. Zhang, Liu, L. Zhang, Zhou, Wang); the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China (L. Zhang, Wang); the CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China (Zhou); and the Department of Psychology, University of Chinese Academy of Sciences, Beijing, China (Zhou) 13661341082@163.com zhouyuan@psych.ac.cn gangwangdoc@ccmu.edu.cn.
Beijing Anding Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroimaging studies have revealed abnormal functional interaction during the processing of emotional faces in patients with major depressive disorder (MDD), thereby enhancing our comprehension of the pathophysiology of MDD. However, it is unclear whether there is abnormal directional interaction among face-processing systems in patients with MDD.

methodsA group of patients with MDD and a healthy control group underwent a face-matching task during functional magnetic resonance imaging. Dynamic causal modelling (DCM) analysis was used to investigate effective connectivity between 7 regions in the face-processing systems. We used a Parametric Empirical Bayes model to compare effective connectivity between patients with MDD and controls.

resultsWe included 48 patients and 44 healthy controls in our analyses. Both groups showed higher accuracy and faster reaction time in the shape-matching condition than in the face-matching condition. However, no significant behavioural or brain activation differences were found between the groups. Using DCM, we found that, compared with controls, patients with MDD showed decreased self-connection in the right dorsolateral prefrontal cortex (DLPFC), amygdala, and fusiform face area (FFA) across task conditions; increased intrinsic connectivity from the right amygdala to the bilateral DLPFC, right FFA, and left amygdala, suggesting an increased intrinsic connectivity centred in the amygdala in the right side of the face-processing systems; both increased and decreased positive intrinsic connectivity in the left side of the face-processing systems; and comparable task modulation effect on connectivity. LIMITATIONS: Our study did not include longitudinal neuroimaging data, and there was limited region of interest selection in the DCM analysis.

conclusionOur findings provide evidence for a complex pattern of alterations in the face-processing systems in patients with MDD, potentially involving the right amygdala to a greater extent. The results confirm some previous findings and highlight the crucial role of the regions on both sides of face-processing systems in the pathophysiology of MDD.

Indexed as

AmygdalaFacial RecognitionMagnetic Resonance ImagingMajor Depressive DisorderAdultBayes TheoremBrainBrain MappingFacial ExpressionFemaleHumansMaleMiddle AgedNeural PathwaysReaction TimeYoung Adult

Identifiers

PMID38692692
PMCPMC11068425
OpenAlexW4396546857

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.