Evidence map›Paper›PMID 38692285›Full record

ArticleNature2024

A body-brain circuit that regulates body inflammatory responses.

Hao Jin, Mengtong Li, Eric Jeong, Felipe Castro-Martinez, Charles S Zuker

Registry-linked trialAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06957912 (Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Quality of Recovery After Major Noncardiac Surgery), which is not on this map. Cited by 214 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06957912 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Quality of Recovery After Major Noncardiac Surgery: A Randomized Trial.

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2026Enrolled320ConditionsVagus Nerve Stimulation, Transcutaneous Electric Nerve Stimulation, Noncardiac Surgery, Quality of RecoveryArmsTranscutaneous auricular vagus nerve stimulation, Sham stimulation
3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Article
  6. Immune dysregulation and epileptogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Vagal sensory neurons profusely innervate the mouse gall bladder.Autonomic neuroscience : basic & clinical · 2026
    Article
  15. Review
  16. Article
  17. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  18. Review
  19. Article
  20. Article

154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hao Jin *Zuckerman Mind Brain Behavior Institute, Howard Hughes Medical Institute, Columbia University, New York, NY, USA. hao.jin@NIH.gov.ORCID 0009-0006-1435-3685
Mengtong Li *Zuckerman Mind Brain Behavior Institute, Howard Hughes Medical Institute, Columbia University, New York, NY, USA.ORCID 0000-0001-6967-7237
Eric JeongZuckerman Mind Brain Behavior Institute, Howard Hughes Medical Institute, Columbia University, New York, NY, USA.
Felipe Castro-MartinezCenter for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Charles S ZukerZuckerman Mind Brain Behavior Institute, Howard Hughes Medical Institute, Columbia University, New York, NY, USA. cz2195@columbia.edu.ORCID 0000-0002-5201-8718

Funding

Elucidating the basis of brain control of innate immune responsesZIAAI001374 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI JIN, HAO · 2023 to 2025
$5.0M
6 · The paper itself

Abstract

The body-brain axis is emerging as a principal conductor of organismal physiology. It senses and controls organ function

Indexed as

BrainCytokinesInflammationNeuroimmunomodulationAnimalsFemaleMaleMiceMice, Inbred C57BLNeuronsSingle-Cell Gene Expression AnalysisVagus NerveCytokines

Identifiers

PMID38692285
PMCPMC11186780

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.