ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024
Development and Standardization of an Osteoradionecrosis Classification System in Head and Neck Cancer: Implementation of a Risk-Based Model.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying risk factors for osteoradionecrosis of the jaws: a systematic review and meta-analysis.Clinical oral investigations · 2026Pooled it
- Microenvironmental barriers to healing in osteoradionecrosis and opportunities for regenerative intervention.Bioactive materials · 2027Review
- Seven-year follow-up demonstrating sustained survival followingOncology letters · 2026Article
- Incidence and Site-Specific Risk Factors of Jaw Osteoradionecrosis for Head and Neck Patients in the IMRT/VMAT Era: Evidence From a Large, Hospital-Based Cohort.Head & neck · 2026Article
- Osteoradionecrosis - an update for the general dental practitioner.British dental journal · 2026Review
- Artificial intelligence (AI) for early identification of radiotherapy related toxicities from the electronic health records of patients with head and neck cancer.Clinical and translational radiation oncology · 2026Article
- Radiomic analysis of pathologically confirmed mandibular osteoradionecrosis to identify cases with associated recurrence: a multicentric retrospective study.Physics and imaging in radiation oncology · 2026Article
- Osteoradionecrosis After Modern Radiotherapy for Oral Cavity Cancer: Incidence and Risk Factors.Laryngoscope investigative otolaryngology · 2026Article
- Post-COVID-19 Jaw Osteonecrosis: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.BMC oral health · 2026Article
- Timing for Radiotherapy Initiation After Dental Extraction and Risk of Osteoradionecrosis in Head and Neck Cancer Patients: A Systematic Review and Meta-Analysis.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Machine Learning Models for Individualized Osteoradionecrosis Risk Prediction in Head and Neck Cancer.Journal of medical systems · 2026Article
- Clinical and dosimetric dataset of time-to-event normal tissue complication probability for osteoradionecrosis.Scientific data · 2026Article
- Decoding Osteoradionecrosis of the Jaw: Radiological Progression and a Novel CT-Based Grading System.Cancers · 2026Article
- Beyond the dose-volume histogram: a critical appraisal of normal tissue complication probability modelling for osteoradionecrosis of the jaw and a strategic framework for clinical translation.Frontiers in oncology · 2026Article
- An ultra-late maxillofacial cavity following multimodal treatment for adult head and neck rhabdomyosarcoma: a case report with a 16-year follow-up.Frontiers in oncology · 2026Article
- Incidence of osteoradionecrosis after dental extractions in head and neck cancer patients: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Radiation-specific Automated Dosimetric dental, Mandible, and maxilla Annotation for Predicting Periodontal Problems (RADMAP): A semi-automated tool for dosimetric oral risk communication and osteoradionecrosis assessment.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Osteoradionecrosis secondary to breast reirradiation.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
purposeOsteoradionecrosis of the jaw (ORN) can manifest in varying severity. The aim of this study is to identify ORN risk factors and develop a novel classification to depict the severity of ORN.
methodsConsecutive patients with head and neck cancer (HNC) treated with curative-intent intensity-modulated radiation therapy (IMRT) (≥45 Gy) from 2011 to 2017 were included. Occurrence of ORN was identified from in-house prospective dental and clinical databases and charts. Multivariable logistic regression model was used to identify risk factors and stratify patients into high-risk and low-risk groups. A novel ORN classification system was developed to depict ORN severity by modifying existing systems and incorporating expert opinion. The performance of the novel system was compared with 15 existing systems for their ability to identify and predict serious ORN event (jaw fracture or requiring jaw resection).
resultsORN was identified in 219 of 2,732 (8%) consecutive patients with HNC. Factors associated with high risk of ORN were oral cavity or oropharyngeal primaries, received IMRT dose ≥60 Gy, current/ex-smokers, and/or stage III to IV periodontal condition. The ORN rate for high-risk versus low-risk patients was 12.7% versus 3.1% (
conclusionWe identified risk factors for ORN and proposed a novel ORN classification system on the basis of vertical extent of bone necrosis and presence/absence of exposed bone/fistula. It outperformed existing systems in depicting the seriousness of ORN and may facilitate clinical care and clinical trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.