Evidence map›Paper›PMID 38691819›Full record

ArticleAdvanced healthcare materials2025

Allergen-Encapsulating Nanoparticles Reprogram Pathogenic Allergen-Specific Th2 Cells to Suppress Food Allergy.

Michael N Saunders, Laila M Rad, Laura A Williams, Jeffrey J Landers, Russell R Urie, Sarah E Hocevar, Miguel Quiros, Ming-Yi Chiang, Amogh R Angadi, Katarzyna W Janczak and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Next-Generation Allergen-Specific Immunotherapy for Food Allergy.Clinical reviews in allergy & immunology · 2025
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 2 countries.

Michael N SaundersDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-5261-6355
Laila M RadDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Laura A WilliamsDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Jeffrey J LandersMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Russell R UrieDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Sarah E HocevarDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Miguel QuirosDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Ming-Yi ChiangDepartment of Microbiology-Immunology, Northwestern University, Chicago, IL, 60611, USA.
Amogh R AngadiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Katarzyna W JanczakMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Elizabeth J BealerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Kelly CrumleyDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Olivia E BensonMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, 48109, USA.
Kate V GriffinDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Brian C RossDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Charles A ParkosDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Asma NusratDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Stephen D MillerDepartment of Microbiology-Immunology, Northwestern University, Chicago, IL, 60611, USA.
Joseph R PodojilDepartment of Microbiology-Immunology, Northwestern University, Chicago, IL, 60611, USA.
Jessica J O'KonekMary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-1455-0586
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-4449-9806
University of Michigan · USNorthwestern University · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
NPs disguised as apoptotic debris for immune toleranceR01AI155678 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STEPHEN D MILLER, Lonnie D Shea · 2020 to 2026
$4.7M
Nanoparticle-mediated reprogramming of circulating monocytes and neutrophils to decrease inflammation-mediated damage after traumaR01AI148076 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDERSON, AILEEN J, SHEA, LONNIE D · 2019 to 2023
$3.4M
NIAID NIH HHS R01 AI148076NIAID NIH HHS R01 AI155678NIGMS NIH HHS T32 GM007863NIH HHS R01AI155678NIH HHS T32GM007863
6 · The paper itself

Abstract

Food allergy is a prevalent, potentially deadly disease caused by inadvertent sensitization to benign food antigens. Pathogenic Th2 cells are a major driver for disease, and allergen-specific immunotherapies (AIT) aim to increase the allergen threshold required to elicit severe allergic symptoms. However, the majority of AIT approaches require lengthy treatments and convey transient disease suppression, likely due to insufficient targeting of pathogenic Th2 responses. Here, the ability of allergen-encapsulating nanoparticles to directly suppress pathogenic Th2 responses and reactivity is investigated in a mouse model of food allergy. NPs associate with pro-tolerogenic antigen presenting cells, provoking accumulation of antigen-specific, functionally suppressive regulatory T cells in the small intestine lamina propria. Two intravenous doses of allergen encapsulated in poly(lactide-co-glycolide) nanoparticles (NPs) significantly reduces oral food challenge (OFC)-induced anaphylaxis. Importantly, NP treatment alters the fates of pathogenic allergen-specific Th2 cells, reprogramming these cells toward CD25

Indexed as

AllergensFood HypersensitivityNanoparticlesTh2 CellsAnimalsDisease Models, AnimalFemaleMiceMice, Inbred BALB CPolylactic Acid-Polyglycolic Acid CopolymerT-Lymphocytes, RegulatoryAllergensPolylactic Acid-Polyglycolic Acid Copolymerallergen‐specific immunotherapy mechanismsallergen‐specific Th2 cellsbiomaterialspolymeric nanoparticlesregulatory T cells

Identifiers

PMID38691819
PMCPMC11527797
OpenAlexW4396562507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.