ArticleScience advances2024
Post-retrieval stress impairs subsequent memory depending on hippocampal memory trace reinstatement during reactivation.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Cortisol suppression impairs retrieval of emotional memory and changes its neural correlates immediately and four days post-treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Stress disrupts hippocampal integration of overlapping events and memory inference in humans.Science advances · 2026Article
- Different Reliance on Sensory Reinstatement and Internally Transformed Representations during Vivid Retrieval of Visual and Auditory Episodes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Prediction Error-Related Memory Enhancement Depends on the Neural State Surrounding the Prediction Error Event.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- Article
- State-dependent memory mechanisms insights from neural circuits and clinical implications.Frontiers in cellular neuroscience · 2025Review
- Long COVID patients' brain activation is suppressed during walking and severer symptoms lead to stronger suppression.European archives of psychiatry and clinical neuroscience · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon retrieval, memories can become susceptible to meaningful events, such as stress. Post-retrieval memory changes may be attributed to an alteration of the original memory trace during reactivation-dependent reconsolidation or, alternatively, to the modification of retrieval-related memory traces that impact future remembering. Hence, how post-retrieval memory changes emerge in the human brain is unknown. In a 3-day functional magnetic resonance imaging study, we show that post-retrieval stress impairs subsequent memory depending on the strength of neural reinstatement of the original memory trace during reactivation, driven by the hippocampus and its cross-talk with neocortical representation areas. Comparison of neural patterns during immediate and final memory testing further revealed that successful retrieval was linked to pattern-dissimilarity in controls, suggesting the use of a different trace, whereas stressed participants relied on the original memory representation. These representation changes were again dependent on neocortical reinstatement during reactivation. Our findings show disruptive stress effects on the consolidation of retrieval-related memory traces that support future remembering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.