ArticleJournal of neurophysiology2024
Evidence of the existence of multiple modules for the stroke-caused flexion synergy from Fugl-Meyer assessment scores.
Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness.eLife · 2026Article
- Characterization of Muscle Synergies During Activities of Daily Living Using Surface EMG: A Functional Reference for Neuromuscular Assessment.Journal of clinical medicine · 2026Article
- Automated Quantification of Movement Qualities in the Human Upper Extremity After Stroke Using a Wearable Robot.Research square · 2026Article
- Insights into the dependence of post-stroke motor recovery on the initial corticospinal tract connectivity from a computational model.Journal of neuroengineering and rehabilitation · 2025Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Stroke-caused synergies may result from the preferential use of the reticulospinal tract (RST) due to damage to the corticospinal tract. The RST branches multiple motoneuron pools across the arm together resulting in gross motor control or abnormal synergies, and accordingly, the controllability of individual muscles decreases. However, it is not clear whether muscles involuntarily activated by abnormal synergy vary depending on the muscles voluntarily activated when motor commands descend through the RST. Studies showed that abnormal synergies may originate from the merging and reweighting of synergies in individuals without neurological deficits. This leads to a hypothesis that those abnormal synergies are still selectively excited depending on the context. In this study, we test this hypothesis, leveraging the Fugl-Meyer assessment that could characterize the neuroanatomical architecture in individuals with a wide range of impairments. We examine the ability to perform an out-of-synergy movement with the flexion synergy caused by either shoulder or elbow loading. The results reveal that about 14% [8/57, 95% confidence interval (5.0%, 23.1%)] of the participants with severe impairment (total Fugl-Meyer score <29) in the chronic phase (6 months after stroke) are able to keep the elbow extended during shoulder loading and keep the shoulder at neutral during elbow loading. Those participants underwent a different course of neural reorganization, which enhanced abnormal synergies in comparison with individuals with mild impairment (
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