Evidence map›Paper›PMID 38691326›Full record

ArticleGenes & genomics2024

Overexpression of TRIM44 mediates the NF-κB pathway to promote the progression of ovarian cancer.

Yang Yu, ShiYing Li, Jialin Sun, Yu Wang, LiangZhen Xie, Ying Guo, Jia Li, FengJuan Han

Abstract read
PubMed Publisher
In one paragraph

Article in Genes & genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. LncRNAFrontiers in oncology · 2025
    Article
  5. Multifaceted role ofMedComm · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yang Yu *Department of Obstetrics and Gynecology, Postdoctoral Mobile Station of Heilongjiang University of Traditional Chinese Medicine, Harbin, 150040, China.
ShiYing Li *Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Jialin SunBiological Science and Technology Department, Heilongjiang Vocational College for Nationalities, Harbin, 150066, China.
Yu WangDepartment of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
LiangZhen XieDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, 150040, Harbin, China.
Ying GuoDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, 150040, Harbin, China.
Jia LiDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, 150040, Harbin, China.
FengJuan HanDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, 150040, Harbin, China. hanfengjuan2004@163.com.
First Affiliated Hospital of Heilongjiang University of Chinese Medicine · CNHeilongjiang University of Chinese Medicine · CNHeilongjiang Vocational Institute of Ecological Engineering · CN

Funding

National Natural Science Foundation of China 82074484National Natural Science Foundation of China 82274566
6 · The paper itself

Abstract

backgroundOvarian cancer (OC) is the second most commonly seen cancer in the US, and patients with OC are commonly diagnosed in the advanced stage. Research into the molecular mechanisms and potential therapeutic targets of OC is becoming increasingly urgent. In our study, we worked to discover the role of TRIM44 in OC development.

objectiveThis study explored whether the overexpression of TRIM44 mediates the NF-kB pathway to promote the progression of OC.

methodsA TRIM44 overexpression model was constructed in SKOV3 cells, and the proliferation ability of the cells was detected using the CCK-8 assay. The migration healing ability of cells was detected using cell scratch assay. Cell migration and invasion were detected using Transwell nesting. TUNEL was applied to detect apoptosis, and ELISA and western blot were used to detect the expression of NF-κB signaling pathway proteins. The pathological changes of the tumor tissues were observed using HE staining in a mouse ovarian cancer xenograft model. Immunofluorescence double staining, RT-PCR, and western blot were used to determine the expression of relevant factors in tumour tissues.

resultsTRIM44 overexpression promoted the proliferation, migration, and invasion of SKOV3 cells in vitro and inhibited apoptosis while enhancing the growth of tumours in vivo. TRIM44 regulated the NF-κB signaling pathway.

conclusionsTRIM44 overexpression can regulate the NF-κB signaling pathway to promote the progression of OC, and TRIM44 may be a potential therapeutic target for OC.

Indexed as

Cell MovementCell ProliferationIntracellular Signaling Peptides and ProteinsNF-kappa BOvarian NeoplasmsSignal TransductionTripartite Motif ProteinsAnimalsApoptosisCell Line, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMiceMice, Inbred BALB CIntracellular Signaling Peptides and ProteinsNF-kappa BTRIM44 protein, humanTripartite Motif ProteinsApoptosisMigration and invasionNF-κB signaling pathwayOvarian cancerTRIM44

Identifiers

PMID38691326
OpenAlexW4396568757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.