Evidence map›Paper›PMID 38691206›Full record

ArticleClinical oral investigations2024

Evaluation of salivary stress markers and inflammatory cytokine levels in peri-implantitis patients.

Fatma Soysal, Berrin Unsal, Sila Cagri Isler, Gulcin Akca, Batuhan Bakirarar, Mustafa Ozcan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Fatma SoysalDepartment of Periodontology, Faculty of Dentistry, Ankara Medipol University, Ankara, Turkey. soysalfatma@gmail.com.
Berrin UnsalDepartment of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Sila Cagri IslerDepartment of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Gulcin AkcaDepartment of Medical Microbiology, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Batuhan BakirararDepartment of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey.
Mustafa OzcanDepartment of Periodontology, Faculty of Dentistry, Cukurova University, Adana, Turkey.
Gazi University · TRAnkara Medipol ÜniversitesiAnkara University · TRCukurova University · TRUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivePsychological stress has been identified in some observational studies as a potential factor that may modify and affect periodontal diseases, but there are no similar data for peri-implantitis. The aim of this study was to determine the relationship between interleukin (IL)-1β, IL-6, IL-10, interferon (IFN)α inflammatory cytokines and the psychological stress-related markers, glucocorticoid receptor-α (GRα), and salivary α-amylase (sAA) gene expression levels in saliva samples obtained from healthy implants and peri-implantitis patients. MATERIALS AND

methodsThe study included a total of 50 systemically healthy subjects. Peri-implant clinical parameters were recorded and psychological stress level was evaluated with the hospital anxiety and depression scale (HAD) and state-trait anxiety inventory (STAI) questionnaire forms. Following the evaluations, the patients were divided into 4 groups according their stress and clinical status (Ia, Ib, IIa, IIb). IL-1β, IL-6, IL-10, IFNα, GRα, sAA gene expression levels in the saliva samples were quantified by quantitative polymerase chain reaction (qPCR).

resultsIn the group of peri-implantitis who had a high score in stress level assessment scales, significantly higher IL-1β, IL-6, sAA expression levels were observed (p < 0.001). The IL-10 gene expression levels were lower in the groups with a high score in the stress level assessment scales (p < 0.001). GRα gene was expressed at lower levels in the group of peri-implantitis who had a high score in stress level assessment scales but the difference was not statistically significant (p = 0.065).

conclusionThe study findings suggest that psychological stress may increase the inflammation associated with peri-implantitis by affecting cytokine expression levels. CLINICAL RELEVANCE: To prevent peri-implantitis or reduce its prevalence, it could be beneficial to evaluate stress levels and identify individuals experiencing stress.

Indexed as

BiomarkersCytokinesPeri-ImplantitisSalivaStress, PsychologicalAdultFemaleHumansMaleMiddle AgedSurveys and QuestionnairesBiomarkersCytokinesBiomarkersPeri-implantitisPsychological stressSaliva

Identifiers

PMID38691206
PMCPMC11062951
OpenAlexW4396547118

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.