Evidence map›Paper›PMID 38691186›Full record

ArticleCell biology and toxicology2024

Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms.

Haisheng Yi, Tong Chen, Guitian He, Lingyun Liu, Jiantao Zhao, Kaimin Guo, Yin Cao, Penghao Sun, Xu Zhou, Boqi Zhang and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Excess copper exposure and male reproductive toxicity: molecular mechanisms and potential interventions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Haisheng YiDepartment of Andrology, The First Hospital of Jilin University, Jilin University, Changchun, 130012, China.
Tong ChenCollege of Animal Sciences, Jilin University, Changchun, 130062, China.
Guitian HeCollege of Animal Sciences, Jilin University, Changchun, 130062, China.
Lingyun LiuDepartment of Andrology, The First Hospital of Jilin University, Jilin University, Changchun, 130012, China.
Jiantao ZhaoDepartment of Andrology, The First Hospital of Jilin University, Jilin University, Changchun, 130012, China.
Kaimin GuoDepartment of Andrology, The First Hospital of Jilin University, Jilin University, Changchun, 130012, China.
Yin CaoDepartment of Andrology, The First Hospital of Jilin University, Jilin University, Changchun, 130012, China.
Penghao SunDepartment of Andrology, The First Hospital of Jilin University, Jilin University, Changchun, 130012, China.
Xu ZhouCollege of Animal Sciences, Jilin University, Changchun, 130062, China. zxu@jlu.edu.cn.
Boqi ZhangCollege of Animal Sciences, Jilin University, Changchun, 130062, China. zzhangbq@jlu.edu.cn.
Chunjin LiCollege of Animal Sciences, Jilin University, Changchun, 130062, China. li_chunjin@jlu.edu.cn.
Hongliang WangDepartment of Andrology, The First Hospital of Jilin University, Jilin University, Changchun, 130012, China. hongliang@jlu.edu.cn.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

Jilin Province Health Technology Capability Enhancement Project 2022JC055Jilin Province Medical and Health Talent Special Project JLSWSRCZX2023-59
6 · The paper itself

Abstract

Copper ionophore NSC319726 has attracted researchers' attention in treating diseases, particularly cancers. However, its potential effects on male reproduction during medication are unclear. This study aimed to determine whether NSC319726 exposure affected the male reproductive system. The reproductive toxicity of NSC319726 was evaluated in male mice following a continuous exposure period of 5 weeks. The result showed that NSC319726 exposure caused testis index reduction, spermatogenesis dysfunction, and architectural damage in the testis and epididymis. The exposure interfered with spermatogonia proliferation, meiosis initiation, sperm count, and sperm morphology. The exposure also disturbed androgen synthesis and blood testis barrier integrity. NSC319726 treatment could elevate the copper ions in the testis to induce cuproptosis in the testis. Copper chelator rescued the elevated copper ions in the testis and partly restored the spermatogenesis dysfunction caused by NSC319726. NSC319726 treatment also decreased the level of retinol dehydrogenase 10 (RDH10), thereby inhibiting the conversion of retinol to retinoic acid, causing the inability to initiate meiosis. Retinoic acid treatment could rescue the meiotic initiation and spermatogenesis while not affecting the intracellular copper ion levels. The study provided an insight into the bio-safety of NSC319726. Retinoic acid could be a potential therapy for spermatogenesis impairment in patients undergoing treatment with NSC319726.

Indexed as

CopperSpermatogenesisTestisTretinoinAnimalsEpididymisMaleMeiosisMiceSpermatogoniaSpermatozoaCopperTretinoinAdjuvant medicationCopper ionophoreCuproptosisNSC319726Retinoic acidSpermatogenesis dysfunction

Identifiers

PMID38691186
PMCPMC11062974
OpenAlexW4396552332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.