Evidence map›Paper›PMID 38690896›Full record

ArticleAntimicrobial agents and chemotherapy2024

A pairwise approach to revitalize β-lactams for the treatment of TB.

Dereje A Negatu, Wassihun Wedajo Aragaw, Véronique Dartois, Thomas Dick

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Dereje A NegatuCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-9205-6842
Wassihun Wedajo AragawCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-4199-2224
Véronique DartoisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-9470-5009
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Hackensack Meridian Health · USGeorgetown University · US

Funding

Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung diseaseR01AI132374 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI Thomas Dick · 2018 to 2026
$7.0M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI132374NIAID NIH HHS R01 AI132374
6 · The paper itself

Abstract

The dual β-lactam approach has been successfully applied to overcome target redundancy in nontuberculous mycobacteria. Surprisingly, this approach has not been leveraged for

Indexed as

Antitubercular Agentsbeta-LactamsMicrobial Sensitivity TestsMycobacterium tuberculosisAmoxicillinAnti-Bacterial AgentsCarbapenemsCefuroximeDrug SynergismHumansTuberculosisAmoxicillinAnti-Bacterial AgentsAntitubercular Agentsbeta-LactamsCarbapenemsCefuroximetebipenemamoxicillincefuroximeMycobacterium tuberculosispotentiationsulopenemtebipenemβ-lactam

Identifiers

PMID38690896
PMCPMC11620507
OpenAlexW4396553551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.