Evidence map›Paper›PMID 38690894›Full record

ArticleAntimicrobial agents and chemotherapy2024

The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistant

Tobias Krogh Nielsen, Ida Birkjær Petersen, Lijuan Xu, Maria Disen Barbuti, Viktor Mebus, Anni Justh, Abdulelah Ahmed Alqarzaee, Nicolas Jacques, Cécile Oury, Vinai Thomas and 3 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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  8. YjbH contributes toVirulence · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Tobias Krogh NielsenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ida Birkjær PetersenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lijuan XuDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Maria Disen BarbutiFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.ORCID 0000-0002-4741-8418
Viktor MebusDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anni JusthDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Abdulelah Ahmed AlqarzaeeCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Nicolas JacquesLaboratory of Cardiology, GIGA Institute, University of Liège Hospital, Liège, Belgium.
Cécile OuryLaboratory of Cardiology, GIGA Institute, University of Liège Hospital, Liège, Belgium.
Vinai ThomasCenter for Staphylococcal Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-7886-0727
Morten KjosFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.ORCID 0000-0003-4448-9082
Camilla HenriksenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dorte FreesDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4946-2890
University of Copenhagen · DKNorwegian University of Life Sciences · NOUniversity of Liège · BEUniversity of Nebraska Medical Center · US

Funding

The Danish Research Council for Independent Research, FTP 0136-00200B
6 · The paper itself

Abstract

Infections caused by methicillin-resistant

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-Lactam Resistancebeta-LactamsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsGene Expression Regulation, BacterialPenicillin-Binding ProteinsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsmecA protein, Staphylococcus aureusPenicillin-Binding Proteinsbeta-lactamsclpXPdaptomycinMRSAnisinoxidative stressSpxtunicamycinvancomycinyjbH

Identifiers

PMID38690894
PMCPMC11620516
OpenAlexW4396553475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.