ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Sleep-wake behavior, perceived fatigability, and cognitive reserve in older adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials.BMC medicine · 2026Pooled it
- Mediating pathways of physical capabilities: linking perceived physical fatigability to motoric cognitive risk syndrome in community older adults.BMC geriatrics · 2026Article
- Waking up to the truth: Associations between sleep disorders and multidomain functional outcomes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sleep quality and possible sarcopenia in community-dwelling older adults: physical and mental fatigability as mediators.BMC geriatrics · 2025Article
- Longitudinal associations between multimodal symptom clusters and functional disability in older adults: a comparative cohort analysis using SHARE, ELSA, and KLoSA.Scientific reports · 2025Article
- The Complex Relationship between Sleep and Cognitive Reserve: A Narrative Review Based on Human Studies.Brain sciences · 2024Review
- Sleep-wake behavior, perceived fatigability, and cognitive reserve in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe effects of sleep-wake behavior on perceived fatigability and cognitive abilities when performing daily activities have not been investigated across levels of cognitive reserve (CR).
methodsCR Index Questionnaire (CRIq) data were collected and subjected to moderated mediation analysis.
resultsIn amnestic mild cognitive impairment (aMCI; n = 41), CR moderated sleep-related impairments (SRIs), and fatigability at low CR (CRIq < 105.8, p = 0.004) and mean CR (CRIq = 126.9, p = 0.03) but not high CR (CRIq > 145.9, p = 0.65) levels. SRI affected cognitive abilities mediated by fatigability at low CR (p < 0.001) and mean CR (p = 0.003) levels. In healthy controls (n = 13), SRI in fatigability did not alter cognitive abilities across CR levels; controls had higher leisure scores than patients with aMCI (p = 0.003, effect size = 0.93). DISCUSSION: SRI can amplify impaired cognitive abilities through exacerbation of fatigability in patients with aMCI with below-mean CR. Therefore, improving sleep-wake regulation and leisure activities may protect against fatigability and cognitive decline. HIGHLIGHTS: Clinical fatigue and fatigability cannot be alleviated by rest. Clinical fatigability disrupts daily activities during preclinical Alzheimer's. High cognitive reserve mitigates sleep-wake disturbance effects. High cognitive reserve attenuates clinical fatigability effects on daily functioning. Untreated obstructive sleep apnea potentiates Alzheimer's pathology in the brain.
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