Evidence map›Paper›PMID 38690440›Full record

ArticleJTCVS open2024

Patient-specific tissue engineered vascular graft for aortic arch reconstruction.

Hidenori Hayashi, Jacqueline Contento, Hiroshi Matsushita, Paige Mass, Vincent Cleveland, Seda Aslan, Amartya Dave, Raquel Dos Santos, Angie Zhu, Emmett Reid and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Small Diameter Vascular Grafts Made in Minutes.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 1 country.

Hidenori HayashiDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Jacqueline ContentoDepartment of Cardiology, Children's National Hospital, Washington, DC.
Hiroshi MatsushitaDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Paige MassDepartment of Cardiology, Children's National Hospital, Washington, DC.
Vincent ClevelandDepartment of Cardiology, Children's National Hospital, Washington, DC.
Seda AslanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Md.
Amartya DaveDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Raquel Dos SantosDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Angie ZhuDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Emmett ReidDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Tatsuya WatanabeDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Nora LeeDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Tyler DunnDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Umar SiddiqiDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Katherine NurminskyDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Vivian NguyenDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.
Keigo KawajiDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Ill.
Joey HuddleNanofiber Solutions, LLC, Dublin, Ohio.
Luka PocivavsekDivision of Vascular Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
Jed JohnsonNanofiber Solutions, LLC, Dublin, Ohio.
Mark FugeDepartment of Mechanical Engineering, University of Maryland, College Park, Md.
Yue-Hin LokeDepartment of Cardiology, Children's National Hospital, Washington, DC.
Axel KriegerDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Md.
Laura OlivieriDepartment of Pediatric Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pa.
Narutoshi HibinoDivision of Cardiac Surgery, Department of Surgery, University of Chicago, Chicago, Ill.
University of Chicago · USChildren's National · USIllinois Institute of Technology · USJohns Hopkins University · USNanofiber Solutions (United States) · USAdvocate Children's Hospital · USUniversity of Maryland, College Park · US

Funding

Patient specific 3D printed tissue engineered vascular graft for aortic reconstruction designed by artificial intelligence algorithm.R01HL143468 · NHLBI · UNIVERSITY OF CHICAGO · PI FUGE, MARK, HIBINO, NARUTOSHI · 2018 to 2021
$2.7M
Patient Specific Tissue Engineered Vascular Graft Creation Using 3D Printing TechnologyR33HD090671 · NICHD · UNIVERSITY OF CHICAGO · PI HIBINO, NARUTOSHI, KRIEGER, AXEL · 2019 to 2021
$1.2M
MR Quantification of Myocardial Oxygen Utilization in Chronic Myocardial Infarction without ContrastK25HL141634 · NHLBI · ILLINOIS INSTITUTE OF TECHNOLOGY · PI KAWAJI, KEIGO · 2019 to 2023
$831k
Patient Specific Tissue Engineered Vascular Graft Creation Using 3D Printing TechnologyR21HD090671 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HIBINO, NARUTOSHI, KRIEGER, AXEL · 2017 to 2018
$484k
NHLBI NIH HHS K25 HL141634NHLBI NIH HHS R01 HL143468NICHD NIH HHS R21 HD090671NICHD NIH HHS R33 HD090671
6 · The paper itself

Abstract

Objectives: The complexity of aortic arch reconstruction due to diverse 3-dimensional geometrical abnormalities is a major challenge. This study introduces 3-dimensional printed tissue-engineered vascular grafts, which can fit patient-specific dimensions, optimize hemodynamics, exhibit antithrombotic and anti-infective properties, and accommodate growth. Methods: We procured cardiac magnetic resonance imaging with 4-dimensional flow for native porcine anatomy (n = 10), from which we designed tissue-engineered vascular grafts for the distal aortic arch, 4 weeks before surgery. An optimal shape of the curved vascular graft was designed using computer-aided design informed by computational fluid dynamics analysis. Grafts were manufactured and implanted into the distal aortic arch of porcine models, and postoperative cardiac magnetic resonance imaging data were collected. Pre- and postimplant hemodynamic data and histology were analyzed. Results: Postoperative magnetic resonance imaging of all pigs with 1:1 ratio of polycaprolactone and poly-L-lactide-co-ε-caprolactone demonstrated no specific dilatation or stenosis of the graft, revealing a positive growth trend in the graft area from the day after surgery to 3 months later, with maintaining a similar shape. The peak wall shear stress of the polycaprolactone/poly-L-lactide-co-ε-caprolactone graft portion did not change significantly between the day after surgery and 3 months later. Immunohistochemistry showed endothelization and smooth muscle layer formation without calcification of the polycaprolactone/poly-L-lactide-co-ε-caprolactone graft. Conclusions: Our patient-specific polycaprolactone/poly-L-lactide-co-ε-caprolactone tissue-engineered vascular grafts demonstrated optimal anatomical fit maintaining ideal hemodynamics and neotissue formation in a porcine model. This study provides a proof of concept of patient-specific tissue-engineered vascular grafts for aortic arch reconstruction.

Indexed as

aortic arch reconstructioncomputational fluid dynamicscongenital heart diseasehemodynamicsshape indextissue engineered vascular graftswall shear stress

Identifiers

PMID38690440
PMCPMC11056495
OpenAlexW4392202840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.