Evidence map›Paper›PMID 38690291›Full record

ArticleRheumatology advances in practice2024

Mortality, bone density and grip strength: lessons from the past and hope for the future?

Leo D Westbury, Faidra Laskou, Harnish P Patel, Cyrus Cooper, Elaine M Dennison

Open access · goldAbstract read
In one paragraph

Article in Rheumatology advances in practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Leo D WestburyMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Faidra LaskouMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Harnish P PatelMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
Cyrus CooperMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0003-3510-0709
Elaine M DennisonMRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
University Hospital Southampton NHS Foundation Trust · GBMRC Lifecourse Epidemiology Unit · GB

Funding

Medical Research Council MC_PC_21001Medical Research Council MC_PC_21003Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/2
6 · The paper itself

Abstract

Objectives: Therapeutic advances in the management of osteoporosis and sarcopenia have occurred at different rates over the last 2 decades. Here we examine associations between grip strength and BMD with subsequent all-cause and cause-specific mortality in a UK community-dwelling cohort. Methods: Data from 495 men and 414 women from the Hertfordshire Cohort Study were analysed. Grip strength was assessed by grip dynamometry, femoral neck BMD was ascertained using DXA and deaths were recorded from baseline (1998-2004) until 31 December 2018. Grip strength and BMD in relation to mortality outcomes (all-cause, cardiovascular-related, cancer-related and mortality due to other causes) were examined using Cox regression with adjustment for age and sex. Results: The mean baseline age of participants was 64.3 years (s.d. 2.5) and 65.9 years (s.d. 2.6) in men and women, respectively. Lower grip strength was associated with increased risk of all-cause mortality [hazard ratio (HR) 1.30 (95% CI 1.06, 1.58), Conclusion: We report strong relationships between grip strength and mortality compared with BMD. We hypothesize that this may reflect better recognition and treatment of low BMD in this cohort.

Indexed as

epidemiologymortalityosteoporosissarcopenia

Identifiers

PMID38690291
PMCPMC11057971
OpenAlexW4393280278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.