Evidence map›Paper›PMID 38690290›Full record

ReviewGastroenterology report2024

Gastrointestinal microbiota-directed nutritional and therapeutic interventions for inflammatory bowel disease: opportunities and challenges.

Devendra Paudel, Divek V T Nair, Grace Joseph, Rita Castro, Amit K Tiwari, Vishal Singh

Open access · diamondAbstract readReview
In one paragraph

Review in Gastroenterology report, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Mulberroside A attenuates HMolecular medicine reports · 2026
    Article
  2. Impact of lactic acid bacteria andVeterinary and animal science · 2026
    Article
  3. Article
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  6. Comparative risk ofTherapeutic advances in gastroenterology · 2026
    Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Devendra PaudelDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
Divek V T NairDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
Grace JosephDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
Rita CastroDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
Amit K TiwariCollege of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Vishal SinghDepartment of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.
Pennsylvania State University · USUniversity of Arkansas for Medical Sciences · US

Funding

Interplay of processed diet, gut microbiota, and interferon-linked mucosal immunity in the onset and prevalence of inflammatory bowel diseaseR01DK133334 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI Vishal Singh · 2023 to 2026
$1.8M
Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training ProgramT32DK120509 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW, PERDEW, GARY H. · 2020 to 2024
$781k
NIDDK NIH HHS R01 DK133334NIDDK NIH HHS T32 DK120509
6 · The paper itself

Abstract

Evidence-based research has confirmed the role of gastrointestinal microbiota in regulating intestinal inflammation. These data have generated interest in developing microbiota-based therapies for the prevention and management of inflammatory bowel disease (IBD). Despite in-depth understanding of the etiology of IBD, it currently lacks a cure and requires ongoing management. Accumulating data suggest that an aberrant gastrointestinal microbiome, often referred to as dysbiosis, is a significant environmental instigator of IBD. Novel microbiome-targeted interventions including prebiotics, probiotics, fecal microbiota transplant, and small molecule microbiome modulators are being evaluated as therapeutic interventions to attenuate intestinal inflammation by restoring a healthy microbiota composition and function. In this review, the effectiveness and challenges of microbiome-centered interventions that have the potential to alleviate intestinal inflammation and improve clinical outcomes of IBD are explored.

Indexed as

dietary fiberdysbiosisfecal microbiota transplantintestinal inflammationmicrobial metabolismmicrobiota restoration therapy

Identifiers

PMID38690290
PMCPMC11057942
OpenAlexW4396234316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.