ArticleFrontiers in medicine2024
Non-AIDS-defining comorbidities impact health related quality of life among older adults living with HIV.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 11 citations in OpenAlex.
- Health-Related Quality of Life in Well-treated People With HIV and Comparators Over an 8-year Period: A Longitudinal Analysis From the Prospective AGEhIV Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Perceptions of Aging from Persons Living and Aging with HIV: A Qualitative Study.Healthcare (Basel, Switzerland) · 2026Article
- The interplay of comorbidity, disability, and physical activity among older adults living with HIV: insights from the CHANGE HIV study.BMC geriatrics · 2026Article
- Association rule mining and network analysis of the evolving comorbidity patterns in HIV inpatients in Baise, China.Frontiers in public health · 2026Article
- Empowerment management program for older adults with HIV/AIDS based on the ADAPT-ITT model: a Chinese Delphi study.BMC health services research · 2025Article
- Immunohematologic parallels and paradoxes: Africa vs Russia in the HIV era- a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Relationship Between Opioid Use, Depression, and Quality of Life Among Persons With HIV at End of Life.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Long-Term Health-Related Quality of Life in People Living with HIV Who Present to Care with AIDS or Severe Immunodeficiency: The CoRIS AIDS Survivors Study.AIDS and behavior · 2025Article
- Prevalence and incidence of human papilloma virus-related dysplasia of oropharyngeal, cervical, and anal mucosae in Spanish people with HIV.AIDS (London, England) · 2025Observational
- Factors Associated with Adequate Quality of Life Levels in HIV Patients During a Five-Year Longitudinal Study.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Observational
- The impact of online and offline social support on the quality of life of HIV/AIDS patients: a cross-sectional study.Frontiers in public health · 2025Article
- Understanding the Triple Burden of HIV, Noncommunicable Diseases, and Mental Health Conditions Among Female Sex Workers With HIV in the Dominican Republic.Journal of the International Association of Providers of AIDS CareArticle
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The life expectancy of people living with HIV receiving effective combination antiretroviral therapy is approaching that of the general population and non AIDS-defining age-related comorbidities are becoming of greater concern. In order to support healthy aging of this population, we set out to explore the association between multimorbidity (defined as presence of 2 or more non AIDS-defining comorbidities) and quality of life (QoL). Methods: We performed a cross-sectional analysis using data from the Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV) study, a Canadian cohort of people living with HIV age 65 years and older. Study participants completed two QoL modules, the general QoL and health related QoL (HR-QoL). Results: 433 participants were included in the analysis with a median age of 69 years (interquartile range, IQR 67-72). The median number of comorbidities among study participants was 3 (IQR 2-4), with 78% meeting the definition of multimorbidity. General QoL scores (median 66, IQR 58-76) were lower than HR-QoL scores (median 71, IQR 61-83) and were not associated with multimorbidity after adjusting for age, sex, relationship status, household income, exercise, tobacco smoking history, malnutrition, time since HIV diagnosis, and HIV-related stigma. In contrast, multimorbidity was associated with lower HR-QoL (adjusted β = -4.57, 95% CI -8.86, -0.28) after accounting for the same variables. Several social vulnerabilities (not having a partner, low household income), health behaviours (lower engagement in exercise, smoking), and HIV-related factors (HIV stigma, longer time since HIV diagnosis) were also associated with lower QoL. Discussion: Overall, our study demonstrated a high burden of multimorbidity among older adults living with HIV in Canada, which has a negative impact on HR-QoL. Interventions aimed at preventing and managing non-AIDS-defining comorbidities should be assessed in people living with HIV to determine whether this can improve their HR-QoL.
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