Evidence map›Paper›PMID 38690082›Full record

ArticleCase reports in neurology

Survival from Rhino-Orbital-Cerebral Mucormycosis in SARS-CoV-2-Positive Diabetic Patients: Two Case Reports.

Claudia Lädrach, Martin Wartenberg, Stefan Zimmerli, Lukas Anschuetz, Stefan Bohlen, Julian Ebner, Claire M F de Gouyon Matignon de Pontouraude, Marco Caversaccio, Franca Wagner

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Pattern-based clinical recognition of diabetes-associatedFrontiers in cellular and infection microbiology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Claudia LädrachDepartment of Ear, Nose and Throat Diseases, Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Martin WartenbergInstitute of Tissue Medicine and Pathology, University Bern, Bern, Switzerland.
Stefan ZimmerliDepartment of Infectious Diseases, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Lukas AnschuetzDepartment of Ear, Nose and Throat Diseases, Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Stefan BohlenDepartment of Neurology, Inselspital, Bern University Hospital, Bern, Switzerland.
Julian EbnerDepartment of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Claire M F de Gouyon Matignon de PontouraudeDepartment of Ophthalmology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Marco CaversaccioDepartment of Ear, Nose and Throat Diseases, Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Franca WagnerDepartment of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
University Hospital of Bern · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Rhino-orbital-cerebral mucormycosis (ROCM) is a rare angioinvasive fungal infection known to be associated with high morbidity and over 50% mortality. ROCM is becoming more common due to an increase in predisposing immunocompromising comorbidities as well as COVID-19. Case Presentations: We report 2 cases - a 75-year-old woman with diabetes and a 39-year-old man with recurrent diabetic ketoacidosis. Both presented initially with acute sinonasal symptoms, were positive for SARS-CoV-2, and diagnosed with acute ROCM. Both underwent mutilating surgical therapy as well as high-dose amphotericin B treatment. With continued oral antifungal treatment, patient 1 showed stable symptoms despite radiographically increasing disease and died of urosepsis 5 months after first surgery. With posaconazole treatment, patient 2 recovered from the disease and showed no clinical sign of disease progression after 1 year. Conclusion: Despite the rarity of the disease, ROCM should be considered if the findings of clinical and radiological examination fit, so that a delay in treatment initiation can be avoided. As our both cases show, survival from ROCM is possible - albeit at a high cost.

Indexed as

Amphotericin BCOVID-19Invasive fungal infectionOrbital apex syndromeRhino-orbital-cerebral mucormycosis

Identifiers

PMID38690082
PMCPMC11057842
OpenAlexW4393403810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.