ReviewFrontiers in bioengineering and biotechnology2024
Platelet-rich fibrin as an autologous biomaterial for bone regeneration: mechanisms, applications, optimization.
Review in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Platelet and Leukocyte Rich Fibrin (L-PRF) in the healing process and bone repair in maxillary sinus lift surgeries: a systematic review.Cell and tissue banking · 2025Pooled it
- Dentine-derived barrier membrane versus extended platelet-rich fibrin for guided bone regeneration: a 2-year randomized clinical trial.BMC oral health · 2026Trial
- Trial
- BMP-7 mRNA delivered by Fibrin-CaP scaffolds activates osteogenic programs in vivo as evidenced by transcriptomic and proteomic analyses.Bioactive materials · 2026Article
- Clinical and Radiographic Evaluation of Plasma Rich in Growth Factors (PRGF) for Alveolar Ridge Preservation in the Anterior Maxilla.Journal of functional biomaterials · 2026Article
- Effects of a Xenogeneic Bone Graft Combined with Platelet-Rich Fibrin Obtained Using Two Distinct Centrifugation Protocols on Critical-Size Rat Calvarial Defects: A Microtomographic, Histomorphometric, and Confocal Laser Scanning Microscopy Analysis.Journal of functional biomaterials · 2026Article
- Oral Mesotherapy as an Adjunctive Approach for the Management of Localized Periodontitis: A Case Report.Cureus · 2026Article
- A Layered Framework for Biological Aesthetics: A Narrative Review of Regenerative Medicine in Cosmetic Science.Cureus · 2026Review
- Dental Pulp Regeneration: A Comprehensive Review of Stem Cells, Biomaterials, and Bioactive Cues.Stem cell reviews and reports · 2026Review
- Outcome Analysis of Leukocyte-Rich Platelet-Rich Plasma, Leukocyte-Poor Platelet-Rich Plasma, and Injectable Platelet-Rich Fibrin in the Management of Chronic Plantar Fasciitis: A Prospective Comparative Study.Journal of orthopaedic case reports · 2026Article
- Review
- PRF-Modified Graft Materials in Lateral Sinus Augmentation: A Systematic Review of Histologic Outcome.Biomedicines · 2026Review
- Analysis of Soft Tissue Healing Over Socket Orifice Sealed with Platelet-Rich Fibrin Membrane.European journal of dentistry · 2026Article
- Platelet-rich fibrin-derived extracellular vesicles: emerging biological mediators in periodontal regeneration.Odontology · 2026Review
- Platelet-derived biomaterials in osteoporosis: mechanisms, evidence and translational prospects.Journal of biological engineering · 2026Review
- The potential of eggshell membrane in bone regeneration: a scoping review of applications and advances.The Saudi dental journal · 2026Review
- The coprecipitation-functionalized 3D-printed GM/PDA/PRF hydrogel for infected bone regeneration via synergistic photothermal antibacterial and osteogenic activity.Materials today. Bio · 2026Article
- Review
- The Impact of Surgical Trauma-Activated Platelet-Rich Fibrin on Mesenchymal Stromal Cells In Vitro.Cells · 2026Article
- Histological and histomorphometric assessment of lateral window sinus augmentation in severe maxillary atrophy using a mixed allograft with β-TCP/HA and autologous platelet-rich fibrin.BMC oral health · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelet-rich fibrin, a classical autologous-derived bioactive material, consists of a fibrin scaffold and its internal loading of growth factors, platelets, and leukocytes, with the gradual degradation of the fibrin scaffold and the slow release of physiological doses of growth factors. PRF promotes vascular regeneration, promotes the proliferation and migration of osteoblast-related cells such as mesenchymal cells, osteoblasts, and osteoclasts while having certain immunomodulatory and anti-bacterial effects. PRF has excellent osteogenic potential and has been widely used in the field of bone tissue engineering and dentistry. However, there are still some limitations of PRF, and the improvement of its biological properties is one of the most important issues to be solved. Therefore, it is often combined with bone tissue engineering scaffolds to enhance its mechanical properties and delay its degradation. In this paper, we present a systematic review of the development of platelet-rich derivatives, the structure and biological properties of PRF, osteogenic mechanisms, applications, and optimization to broaden their clinical applications and provide guidance for their clinical translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.