Evidence map›Paper›PMID 38689510›Full record

ReviewAnimal models and experimental medicine2024

Considerations for the use of porcine organ donation models in preclinical organ donor intervention research.

Frazer I Heinis, Shaheed Merani, Nicholas W Markin, Kim F Duncan, Michael J Moulton, Lance Fristoe, William E Thorell, Raechel A Sherrick, Tami R Wells, Matthew T Andrews and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Animal models and experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Cardioplegic Machine Perfusion of Hearts Donated after Circulatory Death.Journal of cardiovascular translational research · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Frazer I HeinisSchool of Natural Resources, Institute of Agriculture and Natural Resources, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Shaheed MeraniDivision of Transplantation and Vascular Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Nicholas W MarkinDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Kim F DuncanDivision of Cardiothoracic Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Michael J MoultonDivision of Cardiothoracic Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Lance FristoeClinical Perfusion, Nebraska Medicine-Nebraska Medical Center, Omaha, Nebraska, USA.
William E ThorellDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Raechel A SherrickNutrition and Health Sciences, College of Education and Human Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Tami R WellsDepartment of Comparative Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Matthew T AndrewsSchool of Natural Resources, Institute of Agriculture and Natural Resources, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Marian UrbanDivision of Cardiothoracic Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-7907-9297

Funding

Using Patient-Reported Outcomes, Inflammatory Profiles, and Cardiovascular Phenogroups to Expand the Definition of Heart Failure with Preserved Ejection FractionP20GM152326 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Rebekah L. Gundry · 2024 to 2026
$10.3M
University of Nebraska Collaborative Initiative Team Seed Grant #26685
6 · The paper itself

Abstract

Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical transplantation. Animal models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury, organ preservation strategies, and future donor-based interventions. Important considerations include cost, public opinion regarding the conduct of animal research, translational value, and relevance of the animal model for clinical practice. We present an overview of two porcine models of organ donation: donation following brain death (DBD) and donation following circulatory death (DCD). The cardiovascular anatomy and physiology of pigs closely resembles those of humans, making this species the most appropriate for pre-clinical research. Pigs are also considered a potential source of organs for human heart and kidney xenotransplantation. It is imperative to minimize animal loss during procedures that are surgically complex. We present our experience with these models and describe in detail the use cases, procedural approach, challenges, alternatives, and limitations of each model.

Indexed as

Models, AnimalTissue and Organ ProcurementAnimalsBrain DeathHumansOrgan PreservationSwineTissue DonorsTransplantation, Heterologousanimal modelbrain deathcirculatory deathorgan transplantation

Identifiers

PMID38689510
PMCPMC11228092

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.