Evidence map›Paper›PMID 38689326›Full record

ArticleMaternal health, neonatology and perinatology2024

Neonatal blood pressure by birth weight, gestational age, and postnatal age: a systematic review.

Rhys Dore, Katy Barnes, Stephen Bremner, Hiroko Ishii Iwami, Dina Apele-Freimane, Beau Batton, Eugene Dempsey, Ebru Ergenekon, Agnes Klein, Luana Pesco-Koplowitz and 2 more

Open access · goldAbstract read
In one paragraph

Article in Maternal health, neonatology and perinatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
10.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Cardiopulmonary Benefits of Exercise in Adolescents.Advances in experimental medicine and biology · 2026
    Review
  10. Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 7 countries.

Rhys DoreRoyal London Hospital, Barts Health NHS Trust, London, UK.
Katy BarnesDepartment of Neonatology, University Hospitals Sussex, Brighton, UK.
Stephen BremnerBrighton and Sussex Medical School, University of Sussex, Brighton, UK, Eastern Road, BN2 5BE.
Hiroko Ishii IwamiOsaka City General Hospital, Osaka, Japan.
Dina Apele-FreimanePauls Stradins Clinical University Hospital, Riga, Latvia.
Beau BattonSouthern Illinois University School of Medicine, Springfield, IL, USA.
Eugene DempseyUniversity College Cork, Cork, Ireland.
Ebru ErgenekonGazi University, Ankara, Turkey.
Agnes KleinHealth Canada, Ottawa, Canada.
Luana Pesco-KoplowitzDUCK FLATS Pharma LLC, Flemington, New Jersey, USA.
Janis M DionneBritish Columbia Children´S Hospital, Vancouver, Canada.
Heike RabeDepartment of Neonatology, University Hospitals Sussex, Brighton, UK. h.rabe@sussex.ac.uk.
Brighton and Sussex Medical School · GBBarts Health NHS Trust · GBBC Children's Hospital · CAFlow Pharma (United States) · USGazi University · TRHealth Canada · CAOsaka City General Hospital · JPPauls Stradiņš Clinical University Hospital · LVSouthern Illinois University School of Medicine · USUniversity College Cork · IEUniversity Hospitals Sussex NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBlood pressure is a vital hemodynamic marker during the neonatal period. However, normative values are often derived from small observational studies. Understanding the normative range would help to identify ideal thresholds for intervention to treat hypotension or hypertension. Therefore, the aim of this study was to assess observed blood pressure values in neonates who have not received any blood-pressure modifying treatments from birth to three months postnatal age and whether these vary according to birth weight, gestational age and postnatal age.

methodsThis was a systematic review. A literature search was conducted in MEDLINE, PubMed, Embase, Cochrane Library, and CINAHL from 1946 to 2017 on blood pressure in neonates from birth to 3 months of age (PROSPERO ID CRD42018092886). Unpublished data were included where appropriate.

resultsOf 3,587 non-duplicate publications identified, 30 were included (one unpublished study). Twelve studies contained data grouped by birth weight, while 23 contained data grouped by gestational age. Study and clinical heterogeneity precluded meta-analyses thus results are presented by subgroup. A consistent blood pressure rise was associated with increasing birth weight, gestational age, and postnatal age. In addition, blood pressure seemed to rise more rapidly in the most preterm and low birth weight neonates.

conclusionDespite blood pressure increasing with birth weight, gestational age, and postnatal age, there was marked blood pressure variability observed throughout. To better define hypotension and hypertension, future studies should develop consistent approaches for factors related to blood pressure variability, including the method and timing of measurement as well as statistical control of relevant patient characteristics.

Indexed as

Birth weightBlood pressureHypertensionHypotensionNeonatologyPrematurity

Identifiers

PMID38689326
PMCPMC11061963
OpenAlexW4396559059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.