Evidence map›Paper›PMID 38689293›Full record

ReviewJournal of translational medicine2024

Exosomes in the pathogenesis and treatment of cancer-related cachexia.

Qin Ru, Lin Chen, Guodong Xu, Yuxiang Wu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Qin RuInstitute of Intelligent Sport and Proactive Health，Department of Health and Physical Education, Jianghan University, Wuhan, 430056, China.
Lin ChenInstitute of Intelligent Sport and Proactive Health，Department of Health and Physical Education, Jianghan University, Wuhan, 430056, China.
Guodong XuInstitute of Intelligent Sport and Proactive Health，Department of Health and Physical Education, Jianghan University, Wuhan, 430056, China.
Yuxiang WuInstitute of Intelligent Sport and Proactive Health，Department of Health and Physical Education, Jianghan University, Wuhan, 430056, China. yxwu@jhun.edu.cn.ORCID 0000-0002-9041-4471
Jianghan University · CN

Funding

Key Technologies Research and Development Program 2022YFE0111700National Natural Science Foundation of China 81971775National Natural Science Foundation of China 82071970National Natural Science Foundation of China 82272123Science Fund for Distinguished Young Scholars of Hubei Province 2023AFA109
6 · The paper itself

Abstract

Cancer-related cachexia is a metabolic syndrome characterized by weight loss, adipose tissue decomposition, and progressive skeletal muscle atrophy. It is a major complication of many advanced cancers and seriously affects the quality of life and survival of cancer patients. However, the specific molecules that mediate cancer-related cachexia remain elusive, and the fundamental cellular and molecular mechanisms associated with muscle atrophy and lipidolysis in cancer patients still need to be investigated. Exosomes, a newly discovered class of small extracellular vesicles that facilitate intercellular communication, have a significant role in the onset and development of various cancers. Studies have shown that exosomes play a role in the onset and progression of cancer-related cachexia by transporting active molecules such as nucleic acids and proteins. This review aimed to provide an overview of exosome developments in cancer-induced skeletal muscle atrophy and adipose tissue degradation. More importantly, exosomes were shown to have potential as diagnostic markers or therapeutic strategies for cachexia and were prospected, providing novel strategies for the diagnosis and treatment of cancer-related cachexia.

Indexed as

CachexiaExosomesNeoplasmsAdipose TissueAnimalsHumansMuscular AtrophyCancer-related cachexiaExosomesLipidolysisMuscle atrophyNon-coding RNAs

Identifiers

PMID38689293
PMCPMC11062016
OpenAlexW4396530105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.