Evidence map›Paper›PMID 38689277›Full record

ArticleBMC gastroenterology2024

Latent profiles of fatigue in inflammatory bowel disease.

Alex Barnes, Barbara Toson, R V Bryant, Sutapa Mukherjee, Jane M Andrews, Paul Spizzo, Réme Mountifield

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Alex BarnesDepartment of Gastroenterology, Southern Adelaide Local Health Network (SALHN), Flinders Medical Centre, Flinders Drive, Bedford Park, 5042, SA, Australia. alex.barnes@sa.gov.au.
Barbara TosonAdelaide Institute for Sleep Health, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
R V BryantDepartment of Gastroenterology, Queen Elizabeth Hospital, Woodville, SA, Australia.
Sutapa MukherjeeAdelaide Institute for Sleep Health, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Jane M AndrewsSchool of Medicine, Faculty of Health & Medical Sciences, University of Adelaide, Adelaide, SA, Australia.
Paul SpizzoDepartment of Gastroenterology, Southern Adelaide Local Health Network (SALHN), Flinders Medical Centre, Flinders Drive, Bedford Park, 5042, SA, Australia.
Réme MountifieldDepartment of Gastroenterology, Southern Adelaide Local Health Network (SALHN), Flinders Medical Centre, Flinders Drive, Bedford Park, 5042, SA, Australia.
Flinders Medical Centre · AUFlinders University · AUAdelaide Institute for Sleep Health · AUQueen Elizabeth Hospital · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFatigue is prevalent in people with inflammatory bowel disease (IBD) and has been associated with IBD activity, sleep quality, depression, and anxiety. This study aimed to identify fatigue profiles or clusters through latent profile analysis.

methodsAn online questionnaire was administered through three tertiary IBD centres, social media and through Crohn's Colitis Australia. Fatigue was assessed via the Functional assessment of chronic illness measurement system fatigue subscale (FACIT-F), a validated assessment of fatigue and its severity. Validated measures of anxiety, depression, IBD activity and sleep quality were also included. Latent profile analysis was performed including fatigue, sleep quality, active IBD, and depression and anxiety. The relationships between profiles and IBD and demographic data were investigated.

resultsIn a cohort of 535 respondents, 77% were female, the median age was 41 years (range 32-52 years), and the majority had Crohn's disease (62%). Severe fatigue was seen in 62%. Latent profile analysis identified four distinct profiles differing by fatigue score - low fatigue, at-risk profile, active IBD, and a poor mental health profile. Female gender, obesity and opioid usage were associated with higher risk of being in the active IBD and poor mental health profile. Age over 40 was associated with lower risk of being in the poor mental health profile.

conclusionLatent profile analysis identifies four classes of fatigue in an IBD cohort with associations with specific risk factors for fatigue along with specific IBD and demographic attributes. This has implications for the classification of fatigue in IBD and treatment algorithms.

Indexed as

AnxietyDepressionFatigueInflammatory Bowel DiseasesAdultAge FactorsAustraliaCrohn DiseaseFemaleHumansLatent Class AnalysisMaleMiddle AgedRisk FactorsSeverity of Illness IndexSex FactorsAnxietyColitisDepressionFatigueInflammatory bowel diseaseMental healthSleep quality

Identifiers

PMID38689277
PMCPMC11061964
OpenAlexW4396515239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.