Evidence map›Paper›PMID 38689256›Full record

ArticleBMC psychiatry2024

Patient adherence as a predictor of acute and long-term outcomes in concentrated exposure treatment for difficult-to-treat obsessive-compulsive disorder.

Kristian Tjelle, Håvard Berg Opstad, Stian Solem, Gerd Kvale, Michael G Wheaton, Thröstur Björgvinsson, Bjarne Hansen, Kristen Hagen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02656342 (Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02656342 phase4completednot on this map

Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder (OCD). Can D-Cycloserine Enhance and Stabilize the Treatment-response in Relapsed and Non-responding OCD-patients? A Randomized, Double-blind, Placebo-controlled National Study

TypeinterventionalSponsorHaukeland University HospitalRan2015 to 2019Enrolled163ConditionsObsessive-Compulsive DisorderArmsD-Cycloserine, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristian TjelleDepartment of Psychiatry, Møre og Romsdal Hospital Trust, Molde Hospital, Molde, 6412, Norway.
Håvard Berg OpstadDepartment of Psychiatry, Møre og Romsdal Hospital Trust, Molde Hospital, Molde, 6412, Norway.
Stian SolemDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Gerd KvaleBergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.
Michael G WheatonDepartment of Psychology, Barnard College, New York, NY, 10027, USA.
Thröstur BjörgvinssonBehavioral Health Partial Hospital Program, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Bjarne HansenBergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.
Kristen HagenDepartment of Psychiatry, Møre og Romsdal Hospital Trust, Molde Hospital, Molde, 6412, Norway. kristen.hagen@helse-mr.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExposure and response prevention (ERP) is considered the first-line psychotherapy for obsessive-compulsive disorder (OCD). Substantial research supports the effectiveness of ERP, yet a notable portion of patients do not fully respond while others experience relapse. Understanding poor outcomes such as these necessitates further research. This study investigated the role of patient adherence to ERP tasks in concentrated exposure treatment (cET) in a sample who had previously not responded to treatment or relapsed.

methodThe present study included 163 adults with difficult-to-treat OCD. All patients received cET delivered during four consecutive days. Patients' treatment adherence was assessed using the Patient EX/RP Adherence Scale (PEAS-P) after the second and third day of treatment. OCD severity was evaluated at post-treatment, 3-month follow-up, and 1-year follow-up by independent evaluators.

resultsPEAS-P scores during concentrated treatment were associated with OCD-severity at post-treatment, 3-month follow-up, and 1-year follow-up. Moreover, PEAS-P scores predicted 12-month OCD severity adjusting for relevant covariates. Adherence also predicted work- and social functioning at 1-year follow-up.

conclusionsThese results indicate that ERP adherence during the brief period of cET robustly relates to improvement in OCD symptoms and functioning in both the short and long term. Assessing adherence might identify patients at risk of poor outcomes, while improving adherence may enhance ERP for treatment resistant patients.

trial registrationClinicalTrials.gov identifier: NCT02656342.

Indexed as

Implosive TherapyObsessive-Compulsive DisorderPatient ComplianceAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedSeverity of Illness IndexTreatment OutcomeAdherenceB4DTcETDifficult-to-treatERPGroupOCDWork- and social functioning

Identifiers

PMID38689256
PMCPMC11059693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.