Evidence map›Paper›PMID 38689233›Full record

Trial reportBMC immunology2024

The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum.

N L Messina, M Wang, E K Forbes, B Freyne, W P Hasang, S Germano, R Bonnici, F Summons, K Gardiner, S Donath and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01906853 (A Randomised, Controlled Trial to Determine if BCG Immunisation at Birth Reduces Allergy and Infection in Infants), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01906853 phase3completednot on this map

A Randomised, Controlled Trial to Determine if BCG Immunisation at Birth Reduces Allergy and Infection in Infants

TypeinterventionalSponsorMurdoch Childrens Research InstituteRan2013 to 2025Enrolled1,272ConditionsAllergy, Eczema, Respiratory Tract InfectionsArmsBCG
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

N L Messina *Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
M Wang *Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
E K ForbesMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia. emily.forbes@mcri.edu.au.
B FreyneMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
W P HasangDepartment of Infectious Diseases, The Doherty Institute, The University of Melbourne, Melbourne, Australia.
S GermanoMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
R BonniciMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
F SummonsMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
K GardinerMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
S DonathMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
R GordonMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
S J RogersonDepartment of Infectious Diseases, The Doherty Institute, The University of Melbourne, Melbourne, Australia.
N CurtisMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.

Funding

Australian National Health and Medical Research Council GNT1051228Australian National Health and Medical Research Council GNT1092789
6 · The paper itself

Abstract

backgroundBacillus Calmette-Guérin (BCG) vaccination has off-target protective effects against infections unrelated to tuberculosis. Among these, murine and human studies suggest that BCG vaccination may protect against malaria. We investigated whether BCG vaccination influences neonatal in vitro cytokine responses to Plasmodium falciparum. Blood samples were collected from 108 participants in the Melbourne Infant Study BCG for Allergy and Infection Reduction (MIS BAIR) randomised controlled trial (Clinical trials registration NCT01906853, registered July 2013), seven days after randomisation to neonatal BCG (n = 66) or no BCG vaccination (BCG-naïve, n = 42). In vitro cytokine responses were measured following stimulation with P. falciparum-infected erythrocytes (PfIE) or E. coli.

resultsNo difference in the measured cytokines were observed between BCG-vaccinated and BCG-naïve neonates following stimulation with PfIE or E. coli. However, age at which blood was sampled was independently associated with altered cytokine responses to PfIE. Being male was also independently associated with increased TNF-a responses to both PfIE and E. coli.

conclusionThese findings do not support a role for BCG vaccination in influencing in vitro neonatal cytokine responses to P. falciparum. Older neonates are more likely to develop P. falciparum-induced IFN-γ and IFN-γ-inducible chemokine responses implicated in early protection against malaria and malaria pathogenesis.

Indexed as

BCG VaccineCytokinesMalaria, FalciparumPlasmodium falciparumVaccinationErythrocytesEscherichia coliFemaleHumansInfantInfant, NewbornMaleBCG VaccineCytokinesBCGCytokineImmunityMalariaNeonateNon-specific effectsPlasmodium falciparum

Identifiers

PMID38689233
PMCPMC11059926

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.