ArticleNature aging2024
PD1 blockade improves survival and CD8
Abstract read
In one paragraph
Article in Nature aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Engineering Extracellular Vesicles for Anti-Aging Therapy: Mechanisms, Applications, and Perspectives.Aging cell · 2026Review
- The ageing immune system as a driver of systemic ageing.Nature reviews. Immunology · 2026Review
- Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways.Aging cell · 2026Review
- CD8Science China. Life sciences · 2026Review
- Engineering Immune Cell to Counteract Aging and Aging-Associated Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8GeroScience · 2026Article
- Review
- Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications.Translational neurodegeneration · 2025Review
- Aging and immunity: the age-old tango.Genes & development · 2025Review
- Aging reshapes the adaptive immune system from healer to saboteur.Nature aging · 2025Review
- Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8Aging cell · 2025Article
- Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy.Aging and disease · 2025Review
- The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies.Research (Washington, D.C.) · 2025Review
- The Fourth Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Immune-checkpoint blockade protects aged mice from infection.Nature aging · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Korbyn J V DahlquistBiochemistry, Molecular Biology and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-0415-1338
Matthew A HugginsCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Matthew J YousefzadehDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-2869-1029
Carolina Soto-PalmaDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
Stephanie H CholenskyDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
Mark PiersonCenter for Immunology, University of Minnesota, Minneapolis, MN, USA.
Declan M SmithDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
Sara E HamiltonDepartment of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
Christina D CamellBiochemistry, Molecular Biology and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.ORCID http://orcid.org/0000-0001-7847-3543
Funding
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6MUnderstanding the functional agility of effector memory CD8 T cellsR01AI155468 · NIAID · UNIVERSITY OF MINNESOTA · PI HAMILTON HART, SARA ELIZABETH · 2021 to 2025
$2.8MRole of adipose tissue inflammaging and metabolic dysfunction during sepsisR01AG079913 · NIA · UNIVERSITY OF MINNESOTA · PI Christina Camell · 2023 to 2026
$2.2MMacrophage inflammasome activation and the mechanism of lipolysis resistance in aged adiposeR00AG058800 · NIA · UNIVERSITY OF MINNESOTA · PI CAMELL, CHRISTINA · 2019 to 2021
$1.1MRole of PD1 blockade and IL-10 during infection in agingR21AG078638 · NIA · UNIVERSITY OF MINNESOTA · PI CAMELL, CHRISTINA · 2022 to 2023
$413kGlenn Family Foundation AFAR postdoctoral transition awardGlenn Foundation for Medical Research AFAR Grants for Junior FacultyNIAID NIH HHS R01 AI155468NIA NIH HHS R00 AG058800NIA NIH HHS R01 AG079913NIA NIH HHS R21 AG078638NIA NIH HHS T32 AG029796University of Minnesota (UM) Fesler-Lampert Chair on Aging StudiesUniversity of Minnesota (UM) McKnight Land-Grant ProfessorshipU.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R00AG058800U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG079913U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R21AG078638U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) T32AG029796
Abstract
By 2030, individuals 65 years of age or older will make up approximately 20% of the world's population
Indexed as
CD8-Positive T-LymphocytesInflammationProgrammed Cell Death 1 ReceptorAgingAnimalsAntibodies, MonoclonalFemaleImmune Checkpoint InhibitorsMiceMice, Inbred C57BLAntibodies, MonoclonalImmune Checkpoint InhibitorsPdcd1 protein, mouseProgrammed Cell Death 1 Receptor
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.