Evidence map›Paper›PMID 38689062›Full record

ArticleNature medicine2024

Vision-language foundation model for echocardiogram interpretation.

Matthew Christensen, Milos Vukadinovic, Neal Yuan, David Ouyang

Abstract read
In one paragraph

Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. A Facial Foundation Model for Clinical Biomarker Prediction and Real-World Mobile Deployment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  12. Foundation models for cardiovascular diseases and medicine.European heart journal. Digital health · 2026
    Review
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  16. Article
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Matthew ChristensenDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0009-9582-9391
Milos VukadinovicDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Neal YuanDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5782-7437
David OuyangDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. david.ouyang@cshs.org.ORCID 0000-0002-3813-7518

Funding

Deep Learning Based Phenotyping and Outcomes Prediction for Valvular Heart DiseaseR01HL173526 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI David Ouyang · 2024 to 2026
$2.5M
Artificial Intelligence Imaging Biomarkers of Longitudinal Cardiovascular StressR01HL173487 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI David Ouyang · 2025 to 2026
$1.4M
Deep Learning Assessment of the Right Ventricle: Function, Etiology, and PrognosisR00HL157421 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI OUYANG, DAVID · 2023 to 2025
$747k
NHLBI NIH HHS R00 HL157421NHLBI NIH HHS R01 HL173487NHLBI NIH HHS R01 HL173526U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 4R00HL157421-03
6 · The paper itself

Abstract

The development of robust artificial intelligence models for echocardiography has been limited by the availability of annotated clinical data. Here, to address this challenge and improve the performance of cardiac imaging models, we developed EchoCLIP, a vision-language foundation model for echocardiography, that learns the relationship between cardiac ultrasound images and the interpretations of expert cardiologists across a wide range of patients and indications for imaging. After training on 1,032,975 cardiac ultrasound videos and corresponding expert text, EchoCLIP performs well on a diverse range of benchmarks for cardiac image interpretation, despite not having been explicitly trained for individual interpretation tasks. EchoCLIP can assess cardiac function (mean absolute error of 7.1% when predicting left ventricular ejection fraction in an external validation dataset) and identify implanted intracardiac devices (area under the curve (AUC) of 0.84, 0.92 and 0.97 for pacemakers, percutaneous mitral valve repair and artificial aortic valves, respectively). We also developed a long-context variant (EchoCLIP-R) using a custom tokenizer based on common echocardiography concepts. EchoCLIP-R accurately identified unique patients across multiple videos (AUC of 0.86), identified clinical transitions such as heart transplants (AUC of 0.79) and cardiac surgery (AUC 0.77) and enabled robust image-to-text search (mean cross-modal retrieval rank in the top 1% of candidate text reports). These capabilities represent a substantial step toward understanding and applying foundation models in cardiovascular imaging for preliminary interpretation of echocardiographic findings.

Indexed as

EchocardiographyArtificial IntelligenceHumansImage Interpretation, Computer-Assisted

Identifiers

PMID38689062
PMCPMC11108770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.