ArticleNature metabolism2024
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity.
Abstract read
In one paragraph
Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Mitochondrial oxygen metabolism as a potential predictor of weight loss after laparoscopic sleeve gastrectomy for class III obesity.Frontiers in endocrinology · 2024Trial
- Nuclear genetic modulation of tissue-specific mitochondrial RNA processing contributes to common disease risk.Nature communications · 2026Article
- Alternative polyadenylation mediated the downregulation of lysophosphatidylglycerol acyltransferase 1 in metabolic dysfunction-associated steatotic liver disease.Lipids in health and disease · 2026Article
- Fat sensory cues in early life program central response to food and obesity.Nature metabolism · 2025Article
- The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain.Cell death & disease · 2025Article
- Mammalian mitohormesis: from mitochondrial stressors to organismal benefits.The EMBO journal · 2025Review
- Mitochondria dysfunction: cause or consequence of physiologic aging?Genes & development · 2025Review
- Age-dependent accumulation of mitochondrial tRNA mutations in mouse kidneys linked to mitochondrial kidney diseases.Nature aging · 2025Article
- Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes.World journal of gastroenterology · 2025Article
- Mitochondrial genetics, signalling and stress responses.Nature cell biology · 2025Review
- Mitofusin 2 displays fusion-independent roles in proteostasis surveillance.Nature communications · 2025Article
- The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity.Antioxidants (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Shan Jiang *Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Taolin Yuan *Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Florian A RosenbergerDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0000-0003-4604-6170
Arnaud MourierUniversity of Bordeaux, CNRS, Institut de Biochimie et Génétique Cellulaires (IGBC) UMR, Bordeaux, France.ORCID http://orcid.org/0000-0002-5413-611X
Nathalia R V DraganoInstitute of Experimental Genetics - German Mouse Clinic, Helmholtz Zentrum, Munich, Germany.
Laura S KremerDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Diana Rubalcava-GraciaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4615-7375
Fynn M HansenDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.
Melissa BorgDepartment of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Mara MennuniDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Roberta FilogranaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
David AlsinaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Jelena MisicDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Camilla KoolmeisterDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Polyxeni PapadeaDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5131-8196
Martin Hrabe de AngelisInstitute of Experimental Genetics - German Mouse Clinic, Helmholtz Zentrum, Munich, Germany.
Lipeng RenDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Olov AnderssonDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6715-781X
Anke UngerLead Discovery Center, Dortmund, Germany.ORCID http://orcid.org/0000-0003-1288-3763
Tim BergbredeLead Discovery Center, Dortmund, Germany.ORCID http://orcid.org/0000-0002-0930-1884
Raffaella Di LucreziaLead Discovery Center, Dortmund, Germany.ORCID http://orcid.org/0000-0001-6510-9945
Rolf WibomCentre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden.
Juleen R ZierathDepartment of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6891-7497
Anna KrookDepartment of Physiology and Pharmacology, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0891-0258
Patrick GiavaliscoMetabolomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, Germany.ORCID http://orcid.org/0000-0002-4636-1827
Matthias MannDepartment of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany.ORCID http://orcid.org/0000-0003-1292-4799
Nils-Göran LarssonDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. nils-goran.larsson@ki.se.ORCID http://orcid.org/0000-0001-5100-996X
Funding
European Molecular Biology Organization (EMBO) ALTF399-2021European Molecular Biology Organization (EMBO) ALTF570-2019Novo Nordisk Fonden (Novo Nordisk Foundation) NNF20OC006316Swedish Cancer Foundation CAN2018/602Vetenskapsrådet (Swedish Research Council) 2015-00418
Abstract
The oxidative phosphorylation system
Indexed as
Diet, High-FatDNA, MitochondrialObesityTranscription, GeneticAnimalsFatty AcidsFatty LiverLiverMaleMiceMice, Inbred C57BLOxidation-ReductionOxidative PhosphorylationDNA, MitochondrialFatty Acids
Identifiers
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Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.