ArticleNature communications2024
Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania.Science (New York, N.Y.) · 2026Article
- Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles.American journal of human genetics · 2026Article
- Mapping the gene regulatory landscape of archaic hominin introgression in modern Papuans.PLoS genetics · 2026Article
- Human adaptation to high-altitude: A contemporary comparison of the oxygen cascade in Andean, Tibetan and Ethiopian highlanders.Experimental physiology · 2026Review
- Genetic diversity and differentiated adaptive strategies for underrepresented populations at the crossroad of Southeast and East Asia.BMC genomics · 2026Article
- Comparative analysis of pulmonary function in diverse ethnic adults living at low and high altitudes.Respiratory research · 2025Observational
- Differentiating the demographic histories and local adaptations of middle-altitude Qiang and Tibetan people.Human genetics · 2025Article
- Resolving out of Africa event for Papua New Guinean population using neural network.Nature communications · 2025Article
- Anthropometric and metabolic differences and distribution of ABCG2 rs2231142 variant between lowland and highland Papuans in West Papua, Indonesia.Journal of physiological anthropology · 2025Article
- Single cell multiomics and 3D genome architecture reveal novel pathways of human heart failure.medRxiv : the preprint server for health sciences · 2025Article
- Influence of betel nut chewing on oral microbiome in Papua New Guinea.Evolution, medicine, and public health · 2025Article
- A history of multiple Denisovan introgression events in modern humans.Nature genetics · 2024Review
- Genetic history and biological adaptive landscape of the Tujia people inferred from shared haplotypes and alleles.Human genomics · 2024Article
- Genetic Signatures of Positive Selection in Human Populations Adapted to High Altitude in Papua New Guinea.Genome biology and evolution · 2024Article
- Denisovan admixture facilitated environmental adaptation in Papua New Guinean populations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels.Nature communications · 2024Article
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 7 countries.
Funding
Abstract
Highlanders and lowlanders of Papua New Guinea have faced distinct environmental stress, such as hypoxia and environment-specific pathogen exposure, respectively. In this study, we explored the top genomics regions and the candidate driver SNPs for selection in these two populations using newly sequenced whole-genomes of 54 highlanders and 74 lowlanders. We identified two candidate SNPs under selection - one in highlanders, associated with red blood cell traits and another in lowlanders, which is associated with white blood cell count - both potentially influencing the heart rate of Papua New Guineans in opposite directions. We also observed four candidate driver SNPs that exhibit linkage disequilibrium with an introgressed haplotype, highlighting the need to explore the possibility of adaptive introgression within these populations. This study reveals that the signatures of positive selection in highlanders and lowlanders of Papua New Guinea align closely with the challenges they face, which are specific to their environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.