Evidence map›Paper›PMID 38688870›Full record

Observational studyNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2024

Redefining the concept of residual renal function with kidney sodium MRI: a pilot study.

Sandrine Lemoine, Alireza Akbari, Gary Brahm, Justin Dorie, Tanya Tamasi, Jarrin Penny, Christopher W McIntyre

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05014178 (Kidney Sodium Functional Imaging), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05014178 recruitingnot on this map

Kidney Sodium Functional Imaging: Evaluation of Kidney Medullary Sodium Content Using 23Na MRI in Kidney Disease

TypeobservationalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2021 to 2026Enrolled200ConditionsChronic Kidney Disease, Nephrolithiasis, ADPKDArmsSodium-23 MRI
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sandrine LemoineNephrology and Renal Function Department, Hospices Civils de Lyon, Néphrologie-HTA-Dialyse et exploration fonctionnelle rénale, Hôpital Edouard Herriot, Lyon, France.ORCID 0000-0002-3460-2507
Alireza AkbariLilibeth Caberto Kidney Clinical Research Unit, University of Western Ontario, London, Ontario, Canada.
Gary BrahmDepartment of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Justin DorieLilibeth Caberto Kidney Clinical Research Unit, University of Western Ontario, London, Ontario, Canada.
Tanya TamasiLilibeth Caberto Kidney Clinical Research Unit, University of Western Ontario, London, Ontario, Canada.
Jarrin PennyLilibeth Caberto Kidney Clinical Research Unit, University of Western Ontario, London, Ontario, Canada.
Christopher W McIntyreLilibeth Caberto Kidney Clinical Research Unit, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-3877-3135

Funding

Can-SOLVE CKD NetworkCIHR
6 · The paper itself

Abstract

backgroundThe concept of residual kidney function (RKF) is exclusively based upon urine volume and small solute clearance, making RKF challenging to assess in clinical practice. The aim of this study was to test the technical feasibility of obtaining usable sodium magnetic resonance imaging (23Na-MRI) kidney images in hemodialysis (HD) participants.

methodsWe conducted an exploratory prospective study to quantify the cortico-medullary sodium gradient in 17 healthy volunteers and 21 HD participants. Participants fasted for 8 h prior to their study visit. Urine samples were collected to measure urinary osmolarity, before MRI. Proton and sodium pictures were merged; regions of interest were delineated for the medulla and cortex when feasible. In cases where cortex could not be identified, we considered the corticomedullary gradient (CMG) to be no longer present, resulting in a medulla-to-cortex ratio of 1.

resultsMedian (interquartile range) fasting medulla-to-cortex ratio was significantly higher 1.56 (1.5-1.61) in healthy volunteers compared with HD patients 1.22 (1.13-1.3), P < .0001. Medulla to cortex ratio and median urinary osmolarity were correlated (r = 0.87, P < .0001) in the whole population. We found a significant association between HD vintage and medulla-to-cortex ratio, whereas we did not find any association with urine volume. Sodium signal intensity distribution within healthy kidney describes two different peaks relating to well defined cortex and medulla, whereas HD participants displays only a single peak indicative of the markedly lower sodium concentration. LIMITATIONS: This study is only exploratory, with a modest number of patients.

conclusionsThe application of kidney 23Na-MRI to the study of RKF in patients receiving maintenance HD is practical and provides a previously unavailable ability to interrogate the function of remnant tubular function.Clinical Trial Registration: NCT05014178.

Indexed as

KidneyMagnetic Resonance ImagingRenal DialysisSodiumAdultAgedCase-Control StudiesFemaleFollow-Up StudiesGlomerular Filtration RateHumansKidney Failure, ChronicKidney Function TestsMaleMiddle AgedPilot ProjectsSodiumcorticomedullary gradienthaemodialysiskidney residual functionmagnetic resonance imagingsodium

Identifiers

PMID38688870
PMCPMC11648954

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.