ArticleInternational dental journal2024
Systemic Immune-Inflammation Index and Systemic Inflammation Response Index are Associated With Periodontitis: Evidence From NHANES 2009 to 2014.
Article in International dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Body roundness index as a novel marker of periodontitis in US adults: NHANES 2009-2014 analysis.Medicine · 2026Article
- Article
- FAM30A Induces Inflammation and Oxidative Damage in PDLSCs by Targeting miR-424-5p.International dental journal · 2026Article
- Elevated C-reactive Protein Levels and Malignant Transformation Risk in Patients With Oral Mucosal Diseases.International dental journal · 2026Observational
- Systemic immune-inflammation index as a risk factor for acute kidney injury in patients with neonatal jaundice.Translational pediatrics · 2026Article
- Linking systemic inflammation to periodontal disease: insights from blood-derived biomarkers in NHANES.Odontology · 2026Article
- Machine Learning-Based Transcriptomic Diagnosis of Periodontitis.International dental journal · 2026Article
- From health to periodontitis: dynamic changes in the subgingival microbiome and their association with systemic inflammation levels.Frontiers in cellular and infection microbiology · 2026Article
- Lifestyle, Inflammation, and Periodontitis: A National Study Based on the Life's Crucial 9 Framework.Oral health & preventive dentistry · 2025Article
- Observational
- Mediation of Systemic Inflammation Response Index in the Association of Healthy Eating Index-2020 in Patientis with Periodontitis.Oral health & preventive dentistry · 2025Article
- Article
- A cross-sectional study on the relationship between dietary magnesium intake and periodontitis in different body mass index and waist circumference groups: National Health and Nutrition Examination Survey, 2009-2014.Journal of nutritional science · 2025Article
- Life's Crucial 9 score and chronic kidney disease: insights from NHANES 2005-2018 and the mediating role of systemic inflammation and oxidative stress.Frontiers in medicine · 2025Article
- The systemic inflammation response index as a significant predictor of short-term adverse outcomes in acute decompensated heart failure patients: a cohort study from Southern China.Frontiers in endocrinology · 2024Article
- Chronic periodontitis, dantamoolaroga, indicates chronic systemic inflammation and reduces longevity.Journal of Ayurveda and integrative medicineReview
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9 authors.
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Abstract
INTRODUCTION AND
aimsPeriodontitis, a chronic inflammatory condition affecting the supporting structures of the teeth, is a substantial public health burrden whilst impacting the life quality of those affected. Elevated levels of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) have been implicated in various inflammatory conditions. This study aimed to investigate the relationship between SII and SIRI with periodontitis.
methodsThe study examined a total of 8666 participants in the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES). The study compared the weighted prevalence of periodontitis among various groups. The association between SII, SIRI levels, and periodontitis was analyzed using binary logistic regression. Additionally, we explored nonlinear relationships between SII, SIRI, and the prevalence of periodontitis using restricted cubic spline (RCS) plots.
resultsAmong participants in the fourth quartile (Q4) of SII and SIRI, the highest prevalence of periodontitis was observed, with rates of 44.87% and 48.41%, respectively. After adjusting for all covariates, the odds ratio (OR) for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, P = .03), while for SIRI Q4, it was 1.18 (95% CI 1.01, 1.39, P = .04). In addition, the results of sensitivity analysis revealed consistent findings, indicating that after adjusting for all covariates, the OR for periodontitis associated with SII Q4 and SIRI Q4 remained statistically significant. Specifically, the OR for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, P = .03), while for SIRI Q4, it was 1.19 (95% CI 1.01, 1.40, P = .04).
conclusionsThese results indicate that elevated SII and SIRI levels are associated with an increased prevalence of periodontitis. CLINICAL RELEVANCE: These findings suggest a potential connection between systemic inflammation and periodontitis, highlighting the importance of periodontitis patients being aware of their systemic diseases that are inflammatory in nature such as chronic cardiovascular afflictions.
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