ArticleIn vivo (Athens, Greece)
Risk of Keratitis and Keratopathy in Hidradenitis Suppurativa Patients: A Global Federated Health Network Analysis.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Human papillomavirus infection and the risk of uveitis: a propensity-score-matched electronic health record study.Scientific reports · 2026Observational
- Carpal tunnel syndrome as risk factor for subsequent development of irritable bowel syndrome: a retrospective cohort study.Scientific reports · 2026Article
- Hidradenitis Suppurativa and Ocular Diseases: Real-world Evidence of 57,972 Patients.Acta dermato-venereologica · 2025Article
- Renal dysfunction in people with hidradenitis suppurativa: a multi-center, propensity-score-matched cohort study.International journal of medical sciences · 2025Article
- New-Onset Hidradenitis Suppurativa in Psoriasis Patients: A Multi-Center, Retrospective Cohort Study.Life (Basel, Switzerland) · 2024Article
- Risk of Hidradenitis Suppurativa in Patients With Carpal Tunnel Syndrome: A Population-based Cohort Study.In vivo (Athens, Greece)Article
- Risk of Upper Limb Diseases in Osteoarthritis Patients: A Propensity-score-matched Cohort Study.In vivo (Athens, Greece)Article
- Thyroid Diseases After Total Knee Replacement: A Multi-center, Propensity-score-matched Cohort Study.In vivo (Athens, Greece)Article
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Authors and funding
7 authors.
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Abstract
BACKGROUND/
aimHidradenitis suppurativa (HS) is linked to immune dysregulation and systemic inflammation. While previous studies indicate a higher prevalence of ocular manifestations in HS, the specific risk of keratopathy and keratitis remains unclear. The primary aim of this study was to assess the risk of keratitis and keratopathy in individuals with HS. PATIENTS AND
methodsIn this retrospective cohort study conducted with data from the TriNetX database, 53,716 patients with HS were matched to an equivalent number of non-HS controls using propensity score matching. The study covered the period from January 1st, 2005, to December 31st, 2017. Hazard ratios and their respective 95% confidence intervals (CIs), were computed to evaluate the occurrences of keratitis and keratopathy over a 5-year duration in patients with HS, compared to non-HS controls.
resultsHS was associated with a 1.52 times higher risk of keratitis over a 5-year period (95%CI=1.24-1.86) and a 1.47 times higher risk of keratopathy (95%CI=1.18-1.84). These risks remained consistent in sensitivity analyses. The elevated risk of keratitis was observed across both sexes. However, the risk of keratopathy was significantly higher in women with HS (HR=1.61, 95%CI=1.24-2.10) and individuals aged 18-64 years (HR=1.32, 95%CI=1.04-1.68).
conclusionHS was linked to an elevated risk of both keratitis and keratopathy over a 5-year period. Ophthalmologic manifestations are recommended to be considered in HS standard care.
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