ArticleIn vivo (Athens, Greece)
Effects of Excessive High-fructose Corn Syrup Drink Intake in Middle-aged Mice.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- High glucose diet induces hepatic iron overload contributing to metabolic dysfunction.iScience · 2026Article
- The association between high fructose corn syrup and the development of type-2 diabetes.Frontiers in clinical diabetes and healthcare · 2026Review
- Cognitive and neuroanatomical effects of chronic high-fructose corn syrup consumption in the aging rat brain.BMC neuroscience · 2025Article
- Adaptive Responses to High-fructose Corn Syrup Intake Under Energy Restriction in Early Middle-aged Female Mice.In vivo (Athens, Greece)Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimThe global prevalence of type 2 diabetes (T2D) continues to increase, necessitating the need for understanding the causes of its development. The widespread use of high-fructose corn syrup (HFCS) in drinks and diets is suspected to play a role in metabolic disorders. Although many studies have reported on the effects of excessive HFCS and excessive energy intakes in middle-aged individuals, few have focused on energy restriction. This study aimed to investigate the effects of excessive HFCS drink intake under energy restriction on developing T2D in early middle-aged mice. MATERIALS AND
methodsEarly middle-aged mice were divided in HFCS and control groups; they were provided either 10% HFCS water or deionized water ad libitum for 12 weeks, respectively. Total energy intake was controlled using a standard rodent diet. Oral glucose tolerance test (OGTT), insulin tolerance test (ITT), tissue weight measurements, serum parameter analyses, and mRNA expression assessments were performed.
resultsNo increase in body and adipose tissue weight was observed with excessive HFCS intake under energy restriction. Moreover, serum lipid parameters did not differ from those of controls. However, in the OGTT and ITT, the HFCS group showed higher blood glucose levels than the control group. Moreover, the pancreatic weight and insulin II mRNA expression were reduced.
conclusionThe excessive HFCS drink intake under energy restriction did not induce obesity; however, it induced impaired glucose tolerance, indicating its negative effects on the pancreas in early middle-aged mice. When translated in human physiology, our results show that even if one does not become obese, excessive HFCS may affect the overall metabolic mechanism; these effects may vary depending on age.
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