Evidence map›Paper›PMID 38687957›Full record

ArticleJournal of chemical information and modeling2024

Deciphering the Coevolutionary Dynamics of L2 β-Lactamases via Deep Learning.

Yu Zhu, Jing Gu, Zhuoran Zhao, A W Edith Chan, Maria F Mojica, Andrea M Hujer, Robert A Bonomo, Shozeb Haider

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Asymmetric Dynamics Between the Protomers of the σ2 Receptor Homodimer.Journal of chemical information and modeling · 2025
    Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu ZhuPharmaceutical and Biological Chemistry, UCL School of Pharmacy, London WC1N 1AX, U.K.
Jing GuPharmaceutical and Biological Chemistry, UCL School of Pharmacy, London WC1N 1AX, U.K.
Zhuoran ZhaoPharmaceutical and Biological Chemistry, UCL School of Pharmacy, London WC1N 1AX, U.K.
A W Edith ChanDivision of Medicine, UCL School of Pharmacy, London WC1E 6BT, U.K.ORCID 0000-0003-2321-6296
Maria F MojicaDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5029, United States.
Andrea M HujerResearch Service, Department of Veterans Affairs Medical Center, Louis Stokes Cleveland, Cleveland, Ohio 44106-1702, United States.
Robert A BonomoResearch Service, Department of Veterans Affairs Medical Center, Louis Stokes Cleveland, Cleveland, Ohio 44106-1702, United States.ORCID 0000-0002-3299-894X
Shozeb HaiderPharmaceutical and Biological Chemistry, UCL School of Pharmacy, London WC1N 1AX, U.K.ORCID 0000-0003-2650-2925

Funding

The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
BLRD VA I01 BX001974
6 · The paper itself

Abstract

L2 β-lactamases, serine-based class A β-lactamases expressed by

Indexed as

beta-LactamasesDeep LearningMolecular Dynamics SimulationEvolution, MolecularProtein ConformationStenotrophomonas maltophiliabeta-Lactamases

Identifiers

PMID38687957
PMCPMC11094718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.