Evidence map›Paper›PMID 38687843›Full record

SynthesisTrends in psychiatry and psychotherapy2025

Efficacy and suitability of adding short-term psychodynamic psychotherapy (STPP) to pharmacotherapy in patients with depressive disorders: a systematic review.

Gabriele Di Salvo, Camilla Perotti, Valerio Ricci, Giuseppe Maina, Gianluca Rosso

Abstract readSystematic Review
In one paragraph

Synthesis in Trends in psychiatry and psychotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gabriele Di SalvoDepartment of Neurosciences "Rita Levi Montalcini", University of Torino, Turin, Italy. Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
Camilla PerottiDepartment of Neurosciences "Rita Levi Montalcini", University of Torino, Turin, Italy.
Valerio RicciPsychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
Giuseppe MainaDepartment of Neurosciences "Rita Levi Montalcini", University of Torino, Turin, Italy. Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.
Gianluca RossoDepartment of Neurosciences "Rita Levi Montalcini", University of Torino, Turin, Italy. Psychiatric Unit, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRecent guidelines on depressive disorders suggest a combination of antidepressants and psychotherapy in case of moderate to severe symptomatology. While cognitive behavioral therapy (CBT) and interpersonal therapy (ITP) are the most investigated interventions, psychodynamic psychotherapies have been less explored. The aim of this paper is to systematically review literature data on the efficacy of short-term psychodynamic psychotherapy (STPP) in combination with antidepressants in the treatment of depressive disorders, focusing on both short and long-term results and on potential moderators that could influence its effectiveness.

methodsThis systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Databases searched were PubMed, Ovid, Scopus, and Cochrane Library, from inception to August 2023.

resultsAdding STPP to medications in the first 6 months of treatment did not influence remission rates, but did improve acceptability, work adjustment, interpersonal relationships, social role functioning, hospitalization rates, and cost-effectiveness. After 12 months, a significant difference in remission rates arose, favoring combined therapy. From a long-term perspective, adding STPP to pharmacotherapy reduced the recurrence rate by almost 50%. STPP has proven to be more effective in longer depressive episodes, in more severe depression, and in patients with a history of childhood abuse. However, STPP had no impact on major depressive disorder (MDD) with comorbid obsessive-compulsive disorder (OCD).

conclusionsCombining STPP with antidepressants appeared to be helpful from both short-term and long-term perspectives. Still, there are few rigorous studies with large samples and further research is needed to identify which subgroups of patients may benefit more from STPP.

Indexed as

Antidepressive AgentsDepressive DisorderPsychotherapy, BriefPsychotherapy, PsychodynamicCombined Modality TherapyHumansAntidepressive Agentsantidepressantsdepressive disorderspharmacotherapyPsychotherapyshort-term psychodynamic psychotherapy

Identifiers

PMID38687843
PMCPMC12904270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.